Department of Anesthesia, Children's Hospital of Wuhan, Wuhan 430010, China.
Brain Res. 2012 Apr 11;1448:11-9. doi: 10.1016/j.brainres.2012.02.002. Epub 2012 Feb 13.
To explore the response to nociceptive stimuli in spinal cord of immature rat and observe the electrical stimulation of the sciatic nerve on synaptic plasticity of the spinal dorsal horn and spinal c-fos expression in rats of different ages, MK-801 was added to the spinal cord of rats, and the resulting changes in field potential as well as c-fos expression were recorded. LTP in neonatal rats was mainly evoked by A-type nerve fibers, whereas LTP in juvenile and adult rats was mainly evoked by C-type nerve fibers. C-fos expression was significantly increased in the superficial and deep layers of the spinal dorsal horn and in the ventral horn in neonatal rats indicating that the pain signal changed with age.
为了探索幼年大鼠脊髓对伤害性刺激的反应，并观察坐骨神经电刺激对不同年龄大鼠脊髓背角突触可塑性和脊髓 c-fos 表达的影响，在大鼠脊髓中加入了 MK-801，记录了场电位和 c-fos 表达的变化。新生大鼠的 LTP 主要由 A 型神经纤维诱发，而幼鼠和成年大鼠的 LTP 主要由 C 型神经纤维诱发。新生大鼠脊髓背角浅层和深层以及腹角的 c-fos 表达明显增加，表明疼痛信号随年龄变化。
