Department of Chemistry, Kakatiya University, Vidyaranyapuri, Warangal, A.P. 506 009, India.
Eur J Med Chem. 2012 Apr;50:274-9. doi: 10.1016/j.ejmech.2012.02.004. Epub 2012 Feb 10.
A three component one-pot protocol has been investigated for the synthesis of arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides 1 from the commercially available materials. The title compounds 1 were also synthesized by a step-wise method and found to be identical with one-pot synthesis by spectral and analytical data. The newly synthesized compounds were evaluated for their in vitro anticancer activity against human cancer cell lines and in vivo anticancer activity on EAC-bearing mice. Compound 1a was found to be the most active both in in vitro and in vivo cytotoxic studies.
已经研究了一种三组分一锅法，从市售材料合成芳基亚甲基双异恶唑并[4,5-b]吡啶-N-氧化物 1。标题化合物 1 也通过逐步法合成，并通过光谱和分析数据发现与一锅合成相同。新合成的化合物对其在体外对人类癌细胞系的抗癌活性和在 EAC 荷瘤小鼠体内的抗癌活性进行了评估。在体外和体内细胞毒性研究中，化合物 1a 被发现是最活跃的。
