Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden.
Restor Neurol Neurosci. 2012;30(1):9-19. doi: 10.3233/RNN-2011-0606.
There is hope for neural stem and progenitor cells (NSPC) to enhance regeneration when transplanted to the injured brain after traumatic brain injury (TBI). So far, the therapeutic effects of NSPC transplantation have been hampered mainly by the notable death of the transplanted cells. Neuroinflammation may lead to additional cell death after TBI and we hypothesized that survival of grafted NSPC could be enhanced by anti-inflammatory treatment.
Mice that were subjected to controlled cortical impact TBI and grafted with NSPC, were treated with the non-steroidal anti-inflammatory drug ibuprofen.
Ibuprofen was found to down-regulate the TBI-induced inflammatory response. In addition, migrating neuroblasts from transplanted cells were observed near the contusion and in the ipsilateral hippocampus in ibuprofen-treated animals only, suggesting that the anti-inflammatory treatment had beneficial effects on graft survival and/or differentiation. However, Morris Water Maze performance or TBI-induced tissue loss was not influenced by ibuprofen treatment.
Our data suggests that anti-inflammatory strategies may be a complement to enhance the outcome for the cell transplants following TBI.
神经干细胞和祖细胞（NSPC）在创伤性脑损伤（TBI）后移植到受损大脑中，有望增强再生。到目前为止，NSPC 移植的治疗效果主要受到移植细胞明显死亡的阻碍。神经炎症可能导致 TBI 后额外的细胞死亡，我们假设抗炎治疗可以增强移植 NSPC 的存活。
接受皮质撞击 TBI 并移植 NSPC 的小鼠用非甾体抗炎药布洛芬治疗。
发现布洛芬可下调 TBI 诱导的炎症反应。此外，只有在接受布洛芬治疗的动物中，才观察到来自移植细胞的迁移神经母细胞靠近挫伤部位和同侧海马，这表明抗炎治疗对移植物存活和/或分化有有益影响。然而，Morris 水迷宫表现或 TBI 引起的组织损失不受布洛芬治疗的影响。
我们的数据表明，抗炎策略可能是增强 TBI 后细胞移植治疗效果的补充手段。
