Socié Gerard, Peffault de Latour Regis, Bouziz Jean David, Rybojad Michel
AP-HP, Hematology Transplantation, Saint Louis Hospital, 1 Avenue Claude Vellefaux, Paris CEDEX 10, France.
Curr Probl Dermatol. 2012;43:91-100. doi: 10.1159/000335269. Epub 2012 Feb 17.
Despite impressive advances in the field of allogeneic hematopoietic transplantation, graft-versus-host disease (GVHD) remains a significant obstacle to overcome. Whereas our understanding of the pathophysiology of acute GVHD has greatly improved, so has our knowledge of the complexities of the immune system. Much of the immunobiology of GVHD has been gleaned from preclinical models and far less from clinical observations or biological studies in human. In this chapter, we summarize some of the major advances in GVHD pathophysiology, and the potent translation of these from the bench to the bedside.
尽管异基因造血移植领域取得了令人瞩目的进展，但移植物抗宿主病（GVHD）仍然是一个需要克服的重大障碍。虽然我们对急性GVHD病理生理学的理解有了很大提高，但我们对免疫系统复杂性的认识也是如此。GVHD的许多免疫生物学知识来自临床前模型，而从人体临床观察或生物学研究中获得的知识要少得多。在本章中，我们总结了GVHD病理生理学的一些主要进展，以及这些进展从实验室到临床的有效转化。
