Programa de Pós-Graduação em Medicina: Ciências Médicas, Faculdade de Medicina, Rua Ramiro Barcelos 2350, Porto Alegre, Brazil.
Gynecol Obstet Invest. 2012;73(2):113-7. doi: 10.1159/000330700. Epub 2012 Feb 22.
Leiomyomas are the most common tumors of the female reproductive tract and a major public health problem. The mechanism of tumorigenesis is unknown, but evidence suggests that estrogens regulate cell proliferation and myoma growth. This effect might be due to different amounts of estrogen receptors (ERα and ERβ) in normal and myoma tissues and overexpression of aromatase P450 in myomas.
To assess protein expression of ERs and aromatase in leiomyomas and normal adjacent myometrium of premenopausal women.
Samples were collected from 12 premenopausal women admitted for abdominal hysterectomy due to fibroids.
The protein expression of ERα, ERβ and aromatase was similar in leiomyoma and normal myometrium (p = 0.239, p = 0.695 and p = 0.203, respectively).
In this analysis of 12 matched leiomyoma and myometrial samples, the data do not support the theory that overexpression ERα, ERβ and aromatase in uterine leiomyomas compared to adjacent myometrium are the cause of tumor growth. The estrogens may exert their growth-stimulatory effects on leiomyomas intermediated by other elements, such as cytokines and growth or apoptosis factors. The effect of estrogen on the growth and development of fibroids is complex and far from being completely understood.
平滑肌瘤是女性生殖道最常见的肿瘤，也是一个主要的公共卫生问题。肿瘤发生的机制尚不清楚，但有证据表明雌激素调节细胞增殖和肌瘤生长。这种作用可能是由于正常和肌瘤组织中雌激素受体（ERα 和 ERβ）的含量不同，以及在肌瘤中芳香化酶 P450 的过度表达。
评估绝经前妇女的平滑肌瘤和正常邻近子宫肌层中 ERs 和芳香酶的蛋白表达。
从 12 名因肌瘤接受腹部子宫切除术的绝经前妇女中采集样本。
ERα、ERβ 和芳香酶在平滑肌瘤和正常子宫肌层中的蛋白表达相似（p = 0.239、p = 0.695 和 p = 0.203）。
在对 12 对匹配的平滑肌瘤和子宫肌层样本进行的这项分析中，数据不支持与邻近子宫肌层相比，子宫平滑肌瘤中 ERα、ERβ 和芳香酶的过度表达是肿瘤生长的原因的理论。雌激素可能通过细胞因子和生长或凋亡因子等其他因素对平滑肌瘤发挥其生长刺激作用。雌激素对纤维瘤的生长和发育的影响是复杂的，远未完全理解。
