Braun U, Spiess B, Matheis F, Schnetzler C, Trösch L, Drögemüller C, Gerspach C
Department of Farm Animals, University of Zürich, Zürich.
Schweiz Arch Tierheilkd. 2012 Mar;154(3):121-3. doi: 10.1024/0036-7281/a000310.
A five-year-old Brown Swiss bull was referred to the Department of Farm Animals, University of Zurich, because of bilateral epiphora that was unresponsive to treatment. Clinical examination revealed a fistulous opening medial to the medial canthus of both eyes and mucopurulent discharge from both openings. Attempts to flush the nasolacrimal duct via the lacrimal points resulted in the fluid exiting via the fistulous opening. Retrograde flushing of the nasolacrimal duct from the nasolacrimal opening resulted in the flush fluid flowing back out the nasolacrimal opening. Bilateral lacrimal fistula medial to the medial canthus of the eye was diagnosed based on the findings. The same anomaly was diagnosed a year later in 4 related female animals referred to our Department for other reasons. Three of the cases were sired by the bull described above and one was sired by his half-brother. Therefore, an autosomal recessive mode of inheritance of this anomaly was assumed. Clinical, epidemiological and molecular studies of the offspring of both bulls are underway to further investigate this anomaly.
一头五岁的瑞士褐牛因双侧流泪且治疗无效被转诊至苏黎世大学农场动物系。临床检查发现双眼内眦内侧有一个瘘口，两个瘘口均有黏液脓性分泌物。试图通过泪点冲洗鼻泪管时，液体从瘘口流出。从鼻泪开口逆行冲洗鼻泪管时，冲洗液又从鼻泪开口流回。根据这些发现，诊断为双侧泪瘘，位于眼内眦内侧。一年后，另外4只因其他原因转诊至我系的相关雌性动物也被诊断出同样的异常。其中3例是上述公牛的后代，1例是其同父异母兄弟的后代。因此，推测这种异常为常染色体隐性遗传模式。目前正在对这两头公牛的后代进行临床、流行病学和分子研究，以进一步调查这种异常情况。
