Braun Ueli, Jacober Simon, Drögemüller Cord
Department of Farm Animals, Vetsuisse-Faculty, University of Zurich, Winterthurerstrasse 260, CH-8057 Zurich, Switzerland.
BMC Vet Res. 2014 Feb 18;10:44. doi: 10.1186/1746-6148-10-44.
An increased incidence of nasolacrimal duct fistula in the offspring of dam J and three of her sons (bulls A, B and C) prompted a study to investigate the prevalence and clinical manifestation of this anomaly. The dam J, bull B, 255 direct offspring of bulls A, B, and C and eight other direct and indirect offspring of cow J were examined. The periocular region of each animal was examined for unilateral or bilateral nasolacrimal duct fistula and the location, appearance and size of the lesions.
Of 265 cattle examined, 54 had unilateral (n = 24) or bilateral fistula (n = 30). The prevalence of affected offspring differed significantly among the three bulls. The fistulae were located medial to the medial canthus of the eye and were 1 to 10 mm (median, 1 mm) in height and 1 to 12 mm (median, 2 mm) in length. The shape of the opening was circular in 58, oval in 23 and slit-like in three. One other animal had a large opening with an atypical shape and another had an abnormal medial canthus with several fistulous openings. Seventy openings were pigmented and 52 were hairless. The fistulae were clinically significant in 12 animals.
The findings suggest a hereditary cause of nasolacrimal duct fistula in Brown Swiss cattle.
在母牛J及其三个儿子（公牛A、B和C）的后代中，鼻泪管瘘的发病率增加，促使开展一项研究以调查这种异常的患病率和临床表现。对母牛J、公牛B、公牛A、B和C的255个直系后代以及母牛J的其他八个直系和旁系后代进行了检查。检查每只动物的眼周区域，以确定是否存在单侧或双侧鼻泪管瘘以及病变的位置、外观和大小。
在检查的265头牛中，54头有单侧（n = 24）或双侧瘘管（n = 30）。在三头公牛的后代中，受影响后代的患病率差异显著。瘘管位于眼角内侧，高度为1至10毫米（中位数为1毫米），长度为1至12毫米（中位数为2毫米）。开口形状为圆形的有58个，椭圆形的有23个，裂隙状的有3个。另有一头动物有一个形状异常的大开口，另一头动物的内眼角异常，有几个瘘管开口。70个开口有色素沉着，52个无毛。12只动物的瘘管具有临床意义。
研究结果表明，瑞士褐牛鼻泪管瘘存在遗传原因。
