School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, Scotland, UK.
Dalton Trans. 2012 Apr 14;41(14):4060-6. doi: 10.1039/c2dt12069k. Epub 2012 Mar 1.
Hydrogen sulfide is an extremely toxic gas that is also of great interest for biological applications when delivered in the correct amount and at the desired rate. Here we show that the highly porous metal-organic frameworks with the CPO-27 structure can bind the hydrogen sulfide relatively strongly, allowing the storage of the gas for at least several months. Delivered gas is biologically active in preliminary vasodilation studies of porcine arteries, and the structure of the hydrogen sulfide molecules inside the framework has been elucidated using a combination of powder X-ray diffraction and pair distribution function analysis.
硫化氢是一种极其有毒的气体，但当以正确的剂量和所需的速度输送时，它在生物应用中也具有很大的意义。在这里，我们表明具有 CPO-27 结构的高度多孔金属有机骨架可以相对较强地结合硫化氢，从而可以储存气体至少几个月。在初步的猪动脉血管舒张研究中，输送的气体具有生物活性，并且使用粉末 X 射线衍射和配分函数分析的组合阐明了框架内硫化氢分子的结构。
