Incorpora Gemma, Pavone Piero, Polizzi Agata, Cocuzza Mariadonatella, Privitera Michael, Pavone Lorenzo, Ruggieri Martino
Unit of Paediatrics, Garibaldi Hospital, Catania, Italy.
J Child Neurol. 2012 May;27(5):657-62. doi: 10.1177/0883073811436249. Epub 2012 Feb 28.
The authors previously reported on the initial manifestations in a set of female twins, who presented soon after birth with bath-induced paroxysmal events each time they were immersed in a warm water bath. These episodes progressively ceased by the age of 36 months, replaced by paroxysmal episodes of alternating hemiplegia unrelated to water immersion. By age 4 years, the twins developed the classic features of alternating hemiplegia of childhood. Clinical outcomes at the age of 11 years are now reported. Standard and video-electroencephalograms showed a large, slow background activity followed by lower amplitude waves without focal abnormalities or other abnormal findings. This represents the first report on (a) alternating hemiplegia of childhood started with bath-induced paroxysmal episodes; (b) this condition in monozygotic twins; and (c) an 11-year follow-up study in which the twins continue to experience episodes of alternating hemiplegia in the setting of baseline cognitive impairment without epileptic episodes.
作者之前报道了一组女性双胞胎的初始表现，她们在出生后不久每次浸入温水中洗澡时都会出现洗澡诱发的阵发性事件。这些发作在36个月大时逐渐停止，取而代之的是与水浸无关的交替性偏瘫阵发性发作。到4岁时，这对双胞胎出现了儿童交替性偏瘫的典型特征。现将11岁时的临床结果报告如下。标准脑电图和视频脑电图显示背景活动缓慢且波幅较大，随后是波幅较低的波，无局灶性异常或其他异常发现。这是关于以下情况的首次报告：(a) 始于洗澡诱发阵发性发作的儿童交替性偏瘫；(b) 单卵双胞胎中的这种疾病；(c) 一项11年的随访研究，其中双胞胎在基线认知障碍的情况下继续经历交替性偏瘫发作且无癫痫发作。
