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CCX140-B 的特性研究,一种 CCR2 趋化因子受体的口服生物利用拮抗剂,用于治疗 2 型糖尿病及其相关并发症。

Characterization of CCX140-B, an orally bioavailable antagonist of the CCR2 chemokine receptor, for the treatment of type 2 diabetes and associated complications.

出版信息

J Pharmacol Exp Ther. 2012 Jun 5. doi: 10.1124/jpet.111.190918.

Abstract

The following manuscript was published as a Fast Forward article on February 29, 2012: Sullivan TJ, Dairaghi DJ, Krasinski A, Miao Z, Wang Y, Zhao BN, Baumgart T, Berahovich R, Ertl LS, Pennell A, Seitz L, Miao S, Ungashe S, Wei Z, Johnson D, Boring L, Tsou C-L, Charo IF, Bekker P, Schall TJ, and Jaen JC, Characterization of CCX140-B, an orally bioavailable antagonist of the CCR2 chemokine receptor, for the treatment of type 2 diabetes and associated complications. J Pharmacol Exp Ther jpet.111.190918; doi:10.1124/jpet.111.190918 It was later found that the chemical identity of a compound cited in the article, CCX140-B, was not sufficiently disclosed. The authors are unable, at this time, to provide the chemical identity of CCX140-B in accordance with the editorial policies of The Journal of Pharmacology and Experimental Therapeutics. As a result, the authors have voluntarily withdrawn this manuscript from publication. We apologize for any inconvenience this may cause JPET's readers.

摘要

以下手稿于 2012 年 2 月 29 日作为快速发布文章发表:Sullivan TJ、Dairaghi DJ、Krasinski A、Miao Z、Wang Y、Zhao BN、Baumgart T、Berahovich R、Ertl LS、Pennell A、Seitz L、Miao S、Ungashe S、Wei Z、Johnson D、Boring L、Tsou C-L、Charo IF、Bekker P、Schall TJ 和 Jaen JC,描述了一种新型的 CCR2 趋化因子受体拮抗剂 CCX140-B,可用于治疗 2 型糖尿病及其相关并发症。J Pharmacol Exp Ther jpet.111.190918;doi:10.1124/jpet.111.190918 后来发现,文章中引用的化合物 CCX140-B 的化学性质没有充分披露。作者目前无法根据《药理学和实验治疗学杂志》的编辑政策提供 CCX140-B 的化学性质。因此,作者自愿将这篇手稿从出版物中撤回。我们对这可能给 JPET 的读者带来的任何不便表示歉意。

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