疾病过程中趋化因子的精细平衡：运输、炎症与内环境稳定。
The fine balance of chemokines during disease: trafficking, inflammation, and homeostasis.
作者信息
Cardona Sandra M, Garcia Jenny A, Cardona Astrid E
机构信息
Department of Biology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX, USA.
出版信息
Methods Mol Biol. 2013;1013:1-16. doi: 10.1007/978-1-62703-426-5_1.
Abstract
The action of chemokines (or "chemotactic cytokines") is recognized as an integral part of inflammatory and regulatory processes. Leukocyte mobilization during physiological conditions, trafficking of various cell types during pathological conditions, cell activation, and angiogenesis are among the target functions exerted by chemokines upon signaling via their specific receptors. Current research is focused in analyzing changes in chemokine/chemokine receptor patterns during various diseases with the aim to modulate pathological trafficking of cells, or to attract particular cell types to specific tissues. This review focuses on defining the role(s) of certain chemokine ligands and receptors in inflammatory neurological conditions such as multiple sclerosis. In addition, the role(s) of chemokines in neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease is also described, as well as the contribution of chemokines to the pathogenesis of cancer, diabetes, and cardiovascular disease.
摘要
趋化因子（或“趋化性细胞因子”）的作用被认为是炎症和调节过程不可或缺的一部分。生理条件下白细胞的动员、病理条件下各种细胞类型的运输、细胞激活以及血管生成，都是趋化因子通过其特定受体发出信号后所发挥的目标功能。当前的研究集中于分析各种疾病中趋化因子/趋化因子受体模式的变化，目的是调节细胞的病理运输，或吸引特定细胞类型至特定组织。本综述着重于确定某些趋化因子配体和受体在诸如多发性硬化症等炎性神经疾病中的作用。此外，还描述了趋化因子在诸如阿尔茨海默病和帕金森病等神经退行性疾病中的作用，以及趋化因子对癌症、糖尿病和心血管疾病发病机制的影响。
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本文引用的文献
1
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Cytokine. 2012 Oct;60(1):1-12. doi: 10.1016/j.cyto.2012.06.018. Epub 2012 Jul 4.
2
The role of CXC chemokines and their receptors in the progression and treatment of tumors.CXC 趋化因子及其受体在肿瘤进展和治疗中的作用。
J Mol Histol. 2012 Dec;43(6):699-713. doi: 10.1007/s10735-012-9435-x. Epub 2012 Jun 30.
3
The biochemistry and biology of the atypical chemokine receptors.非典型趋化因子受体的生物化学和生物学。
Immunol Lett. 2012 Jul 30;145(1-2):30-8. doi: 10.1016/j.imlet.2012.04.004.
4
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5
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6
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Acta Neuropathol. 2012 Oct;124(4):491-503. doi: 10.1007/s00401-012-0989-1. Epub 2012 Apr 22.
7
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Diabetologia. 2012 Aug;55(8):2238-45. doi: 10.1007/s00125-012-2547-8. Epub 2012 Apr 11.
9
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Diabetes. 2012 Jul;61(7):1680-90. doi: 10.2337/db11-1506. Epub 2012 Apr 3.
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