黏液瘤病毒 M064 是痘病毒 C7L 超家族宿主范围因子的一个新成员，它控制着黏液瘤病在欧洲兔中的动力学。
Myxoma virus M064 is a novel member of the poxvirus C7L superfamily of host range factors that controls the kinetics of myxomatosis in European rabbits.
机构信息
Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida, USA.
出版信息
J Virol. 2012 May;86(9):5371-5. doi: 10.1128/JVI.06933-11. Epub 2012 Feb 29.
Abstract
The myxoma virus (MYXV) carries three tandem C7L-like host range genes (M062R, M063R, and M064R). However, despite the fact that the sequences of these three genes are similar, they possess very distinctive functions in vivo. The role of M064 in MYXV pathogenesis was investigated and compared to the roles of M062 and M063. We report that M064 is a virulence factor that contributes to MYXV pathogenesis but lacks the host range properties associated with M062 and M063.
摘要
黏液瘤病毒 (MYXV) 携带三个串联的 C7L 样宿主范围基因 (M062R、M063R 和 M064R)。然而，尽管这三个基因的序列相似，但它们在体内具有非常独特的功能。研究了 M064 在 MYXV 发病机制中的作用，并与 M062 和 M063 的作用进行了比较。我们报告 M064 是一种毒力因子，有助于 MYXV 的发病机制，但缺乏与 M062 和 M063 相关的宿主范围特性。
相似文献
1
Myxoma virus M064 is a novel member of the poxvirus C7L superfamily of host range factors that controls the kinetics of myxomatosis in European rabbits.
J Virol. 2012 May;86(9):5371-5. doi: 10.1128/JVI.06933-11. Epub 2012 Feb 29.
2
Disruption of M-T5, a novel myxoma virus gene member of poxvirus host range superfamily, results in dramatic attenuation of myxomatosis in infected European rabbits.
J Virol. 1996 Jul;70(7):4394-410. doi: 10.1128/JVI.70.7.4394-4410.1996.
3
M062 is a host range factor essential for myxoma virus pathogenesis and functions as an antagonist of host SAMD9 in human cells.
J Virol. 2011 Apr;85(7):3270-82. doi: 10.1128/JVI.02243-10. Epub 2011 Jan 19.
4
Comparative analysis of the complete genome sequence of the California MSW strain of myxoma virus reveals potential host adaptations.
J Virol. 2013 Nov;87(22):12080-9. doi: 10.1128/JVI.01923-13. Epub 2013 Aug 28.
5
M148R and M149R are two virulence factors for myxoma virus pathogenesis in the European rabbit.
Vet Res. 2009 Jan-Feb;40(1):11. doi: 10.1051/vetres:2008049. Epub 2008 Nov 19.
6
Myxoma virus lacking the host range determinant M062 stimulates cGAS-dependent type 1 interferon response and unique transcriptomic changes in human monocytes/macrophages.
PLoS Pathog. 2022 Sep 14;18(9):e1010316. doi: 10.1371/journal.ppat.1010316. eCollection 2022 Sep.
7
Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replication.
PLoS Pathog. 2013;9(7):e1003465. doi: 10.1371/journal.ppat.1003465. Epub 2013 Jul 4.
8
Myxoma virus M-T7, a secreted homolog of the interferon-gamma receptor, is a critical virulence factor for the development of myxomatosis in European rabbits.
Virology. 1996 Jan 1;215(1):17-30. doi: 10.1006/viro.1996.0003.
9
The α2,3-sialyltransferase encoded by myxoma virus is a virulence factor that contributes to immunosuppression.
PLoS One. 2015 Feb 23;10(2):e0118806. doi: 10.1371/journal.pone.0118806. eCollection 2015.
10
Myxoma virus M063R is a host range gene essential for virus replication in rabbit cells.
Virology. 2007 Apr 25;361(1):123-32. doi: 10.1016/j.virol.2006.11.015. Epub 2006 Dec 20.
引用本文的文献
1
The Role of Myxoma Virus Immune Modulators and Host Range Factors in Pathogenesis and Species Leaping.
Viruses. 2025 Aug 21;17(8):1145. doi: 10.3390/v17081145.
2
Cross-species transmission and host range genes in poxviruses.
Virol Sin. 2024 Apr;39(2):177-193. doi: 10.1016/j.virs.2024.01.007. Epub 2024 Jan 23.
3
Molecular Mechanisms of Poxvirus Evolution.
mBio. 2023 Feb 28;14(1):e0152622. doi: 10.1128/mbio.01526-22. Epub 2022 Dec 14.
4
Myxoma virus lacking the host range determinant M062 stimulates cGAS-dependent type 1 interferon response and unique transcriptomic changes in human monocytes/macrophages.
PLoS Pathog. 2022 Sep 14;18(9):e1010316. doi: 10.1371/journal.ppat.1010316. eCollection 2022 Sep.
5
Identification of a Novel Myxoma Virus C7-Like Host Range Factor That Enabled a Species Leap from Rabbits to Hares.
mBio. 2022 Apr 26;13(2):e0346121. doi: 10.1128/mbio.03461-21. Epub 2022 Mar 30.
6
Construction and purification of ANK gene deleted recombinant goatpox virus.
Virusdisease. 2020 Dec;31(4):526-533. doi: 10.1007/s13337-020-00620-z. Epub 2020 Aug 10.
7
Genetic Characterization of a Recombinant Myxoma Virus in the Iberian Hare ().
Viruses. 2019 Jun 7;11(6):530. doi: 10.3390/v11060530.
8
Poxviruses as Gene Therapy Vectors: Generating Poxviral Vectors Expressing Therapeutic Transgenes.
Methods Mol Biol. 2019;1937:189-209. doi: 10.1007/978-1-4939-9065-8_11.
9
Poxvirus Host Range Genes and Virus-Host Spectrum: A Critical Review.
Viruses. 2017 Nov 7;9(11):331. doi: 10.3390/v9110331.
10
Myxoma Virus Optimizes Cisplatin for the Treatment of Ovarian Cancer In Vitro and in a Syngeneic Murine Dissemination Model.
Mol Ther Oncolytics. 2017 Aug 9;6:90-99. doi: 10.1016/j.omto.2017.08.002. eCollection 2017 Sep 15.
本文引用的文献
1
Myxoma virus lacking the pyrin-like protein M013 is sensed in human myeloid cells by both NLRP3 and multiple Toll-like receptors, which independently activate the inflammasome and NF-κB innate response pathways.
J Virol. 2011 Dec;85(23):12505-17. doi: 10.1128/JVI.00410-11. Epub 2011 Sep 28.
2
M062 is a host range factor essential for myxoma virus pathogenesis and functions as an antagonist of host SAMD9 in human cells.
J Virol. 2011 Apr;85(7):3270-82. doi: 10.1128/JVI.02243-10. Epub 2011 Jan 19.
3
The immunoregulatory properties of oncolytic myxoma virus and their implications in therapeutics.
Microbes Infect. 2010 Dec;12(14-15):1144-52. doi: 10.1016/j.micinf.2010.08.012. Epub 2010 Sep 9.
4
Temperature-sensitive mutant in the vaccinia virus E6 protein produce virions that are transcriptionally inactive.
Virology. 2010 Apr 10;399(2):221-30. doi: 10.1016/j.virol.2010.01.010. Epub 2010 Feb 8.
5
Vaccinia virus K1L and C7L inhibit antiviral activities induced by type I interferons.
J Virol. 2009 Oct;83(20):10627-36. doi: 10.1128/JVI.01260-09. Epub 2009 Aug 5.
6
Myxoma virus expressing interleukin-15 fails to cause lethal myxomatosis in European rabbits.
J Virol. 2009 Jun;83(11):5933-8. doi: 10.1128/JVI.00204-09. Epub 2009 Mar 11.
7
Genome comparison of a nonpathogenic myxoma virus field strain with its ancestor, the virulent Lausanne strain.
J Virol. 2009 Mar;83(5):2397-403. doi: 10.1128/JVI.02189-08. Epub 2008 Dec 17.
8
Identification from diverse mammalian poxviruses of host-range regulatory genes functioning equivalently to vaccinia virus C7L.
Virology. 2008 Mar 15;372(2):372-83. doi: 10.1016/j.virol.2007.10.023. Epub 2007 Dec 3.
9
Vaccinia virus temperature-sensitive mutants in the A28 gene produce non-infectious virions that bind to cells but are defective in entry.
Virology. 2007 Sep 15;366(1):62-72. doi: 10.1016/j.virol.2007.03.060. Epub 2007 May 17.
10
Myxoma virus M063R is a host range gene essential for virus replication in rabbit cells.
Virology. 2007 Apr 25;361(1):123-32. doi: 10.1016/j.virol.2006.11.015. Epub 2006 Dec 20.
Zotero 插件