Vasil'eva D K, Goriacheva L G, Monakhova N E
Eksp Klin Farmakol. 2011;74(12):33-5.
Features of the immune response of children with chronic hepatitis C to the antiviral and pathogenetic therapy have been studied. It is shown that the antiviral therapy is accompanied by stimulation of the immune response as manifested by the synthesis of cytokines (IL-4, IFN-alpha, IFN-gamma) with retention of increased production of IFN-a for more than two years after the end of the course of treatment. In children that previously received interferon inductor (cycloferon) for 12 months, high level of IFN-a production is retained, which ensures antiviral protection. Phytotherapy did not influence the production of cytokines.
对慢性丙型肝炎患儿对抗病毒和发病机制治疗的免疫反应特征进行了研究。结果表明，抗病毒治疗伴随着免疫反应的刺激，表现为细胞因子（IL-4、IFN-α、IFN-γ）的合成，且在治疗疗程结束后两年多的时间里，IFN-α的产生持续增加。在先前接受干扰素诱导剂（环孢菌素）治疗12个月的儿童中，IFN-α的高水平产生得以维持，从而确保了抗病毒保护作用。植物疗法并未影响细胞因子的产生。
