Department of Experimental and Clinical Pharmacology and Toxicology, Albert-Ludwigs-University, Freiburg, Germany.
J Neurochem. 2012 May;121(4):597-606. doi: 10.1111/j.1471-4159.2012.07719.x. Epub 2012 Mar 21.
J. Neurochem. (2012) 121, 597-606.
In cultured rat neocortical interneurons, we have studied the effect of long-term application of NMDA or AMPA on the surface density of the NMDA (GluN) receptor subunits GluN1 and GluN2B. Stimulation of Ca(2+) -permeable AMPA (GluA) receptors located on the interneurons decreased the response of GluN receptors. The reduction was caused by a decrease in the surface density of GluN1/GluN2B subunits. In contrast, stimulation of GluN receptors located on the interneurons enhanced the surface density of GluN1/GluN2B subunits. Both effects could be induced by network activation.
J. Neurochem.（2012）121，597-606.
在培养的大鼠新皮质中间神经元中，我们研究了长期应用 NMDA 或 AMPA 对 NMDA（GluN）受体亚基 GluN1 和 GluN2B 表面密度的影响。位于中间神经元上的 Ca2+通透性 AMPA（GluA）受体的刺激降低了 GluN 受体的反应。这种减少是由 GluN1/GluN2B 亚基的表面密度降低引起的。相比之下，位于中间神经元上的 GluN 受体的刺激增强了 GluN1/GluN2B 亚基的表面密度。这两种作用都可以通过网络激活来诱导。
