常见疾病的基因定位：躁郁症和精神分裂症面临的挑战

Genetic mapping of common diseases: the challenges of manic-depressive illness and schizophrenia.

作者信息

Gershon E S, Martinez M, Goldin L R, Gejman P V

机构信息

Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, MD 20892.

出版信息

Trends Genet. 1990 Sep;6(9):282-7. doi: 10.1016/0168-9525(90)90233-v.

DOI:10.1016/0168-9525(90)90233-v

PMID:2238085

Abstract

Advances in genetic mapping of human diseases have led to the identification of single locus susceptibility for several common disorders. There have been a number of reports of linkage for the psychiatric disorders manic-depressive illness and schizophrenia, but none of these linkage reports is uncontested. Nonetheless, it appears promising to continue attempts to map these psychiatric disorders, since linkage can now be detected even when the inheritance is complex and includes genetic heterogeneity and variable penetrance.

摘要

人类疾病基因图谱绘制方面的进展已促使人们识别出几种常见疾病的单基因座易感性。有许多关于躁郁症和精神分裂症这两种精神疾病连锁关系的报告，但这些连锁关系报告无一毫无争议。尽管如此，继续尝试绘制这些精神疾病的图谱似乎很有前景，因为即使遗传情况复杂，包括遗传异质性和可变外显率，现在也能够检测到连锁关系。