Department of Bioenvironmental Systems Engineering, National Taiwan University, Number 1, Section 4, Roosevelt Road, Taipei 106, Taiwan.
J Agric Food Chem. 2012 Mar 28;60(12):3092-7. doi: 10.1021/jf2045284. Epub 2012 Mar 15.
Cinnamomum osmophloeum Kaneh is an indigenous tree species in Taiwan. In this study, phytochemical characteristics and antioxidant activities of the essential oils and key constituents from the leaves of two C. osmophloeum clones were investigated. The two trees possess two chemotypes, which were classified as the cinnamaldehyde type and camphor type. We demonstrated that the essential oils from C. osmophloeum leaves exerted in vivo antioxidant activities in Caenorhabditis elegans. In addition, trans-cinnamaldehyde and D-(+)-camphor, which respectively represent the major compounds in the cinnamaldehyde-type and camphor-type trees, exerted significant in vivo antioxidant activities against juglone-induced oxidative stress in C. elegans. Moreover, expressions of antioxidative-related genes, including superoxide dismutase (SOD) and glutathione S-transferase (GST), were significantly induced by trans-cinnamaldehyde and D-(+)-camphor from C. osmophloeum leaves. Our results showed that the essential oils from C. osmophloeum leaves and their major compounds might have good potential for further development as nutraceuticals or antioxidant remedies.
肉桂是台湾特有的树种。本研究旨在探讨两种肉桂克隆植物叶片精油的化学成分特征和抗氧化活性。这两棵树具有两种化学型，分别归类为肉桂醛型和樟脑型。我们证明了肉桂叶片精油在秀丽隐杆线虫体内具有抗氧化活性。此外，反式肉桂醛和 D-（+）-樟脑分别代表肉桂醛型和樟脑型树木中的主要化合物，在秀丽隐杆线虫体内对胡桃醌诱导的氧化应激具有显著的抗氧化活性。此外，抗氧化相关基因的表达，包括超氧化物歧化酶（SOD）和谷胱甘肽 S-转移酶（GST），均显著受肉桂叶片中的反式肉桂醛和 D-（+）-樟脑诱导。我们的结果表明，肉桂叶片精油及其主要化合物可能具有作为营养保健品或抗氧化剂的良好潜力。
