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用于设计婴幼儿龋病有效干预措施的仿真模型。

A simulation model for designing effective interventions in early childhood caries.

机构信息

Learning Environments, Wayland, Massachusetts, USA.

出版信息

Prev Chronic Dis. 2012;9:E66. doi: 10.5888/pcd9.110219. Epub 2012 Mar 1.

Abstract

INTRODUCTION

Early childhood caries (ECC)--tooth decay among children younger than 6 years--is prevalent and consequential, affecting nearly half of US 5-year-olds, despite being highly preventable. Various interventions have been explored to limit caries activity leading to cavities, but little is known about the long-term effects and costs of these interventions. We developed a system dynamics model to determine which interventions, singly and in combination, could have the greatest effect in reducing caries experience and cost in a population of children aged birth to 5 years.

METHODS

System dynamics is a computer simulation technique useful to policy makers in choosing the most appropriate interventions for their populations. This study of Colorado preschool children models 6 categories of ECC intervention--applying fluorides, limiting cariogenic bacterial transmission from mothers to children, using xylitol directly with children, clinical treatment, motivational interviewing, and combinations of these--to compare their relative effect and cost.

RESULTS

The model projects 10-year intervention costs ranging from $6 million to $245 million and relative reductions in cavity prevalence ranging from none to 79.1% from the baseline. Interventions targeting the youngest children take 2 to 4 years longer to affect the entire population of preschool-age children but ultimately exert a greater benefit in reducing ECC; interventions targeting the highest-risk children provide the greatest return on investment, and combined interventions that target ECC at several stages of its natural history have the greatest potential for cavity reduction. Some interventions save more in dental repair than their cost; all produce substantial reductions in repair cost.

CONCLUSION

By using data relevant to any geographic area, this system model can provide policy makers with information to maximize the return on public health and clinical care investments.

摘要

简介

婴幼儿龋(ECC)——6 岁以下儿童的龋齿——在美国 5 岁儿童中发病率接近一半,且后果严重,但由于其具有高度可预防性,因此仍然广泛存在。人们已经探索了各种干预措施来限制导致龋齿的致龋菌活动,但对于这些干预措施的长期效果和成本却知之甚少。我们开发了一个系统动力学模型,以确定在出生至 5 岁的儿童人群中,哪些单一或联合干预措施可以最大程度地减少龋齿发生和成本。

方法

系统动力学是一种计算机模拟技术,对决策者选择适合其人群的干预措施非常有用。本研究以科罗拉多州学龄前儿童为模型,对 6 类 ECC 干预措施进行建模,包括应用氟化物、限制母亲向儿童传播致龋菌、直接用木糖醇治疗儿童、临床治疗、动机访谈以及这些措施的组合,以比较它们的相对效果和成本。

结果

该模型预测,10 年干预成本范围为 600 万美元至 2.45 亿美元,相对龋齿患病率降低范围从无到 79.1%。针对最年幼儿童的干预措施需要 2 至 4 年的时间才能影响到整个学龄前儿童人群,但最终在减少 ECC 方面会产生更大的效益;针对高风险儿童的干预措施具有最高的投资回报率,针对 ECC 在其自然史的几个阶段进行的联合干预措施具有最大的减少龋齿的潜力。一些干预措施在修复方面的节省超过了其成本;所有干预措施都能显著降低修复成本。

结论

通过使用与任何地理区域相关的数据,这个系统模型可以为决策者提供信息,以最大限度地提高公共卫生和临床护理投资的回报。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7707/3366771/a6bc2564526c/PCD-9-E66s01.jpg

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