Watanabe Noriyoshi, Suzuki Tomo, Kitano Etsuko, Kitamura Hajime, Hatanaka Michiyo, Sago Haruhiko
Department of Maternal-Fetal and Neonatal Medicine, National Center for Child Health and Development, Tokyo, Japan.
J Obstet Gynaecol Res. 2012 Mar;38(3):562-6. doi: 10.1111/j.1447-0756.2011.01731.x. Epub 2012 Feb 16.
Complement component 9 (C9) deficiency is relatively common, especially in Japan. Here we present the case of a 27-year-old Japanese woman whose obstetric history involved three mid-trimester miscarriages (at 22 weeks', 18 weeks' and 21 weeks' gestation) and one early spontaneous miscarriage. Her fifth pregnancy was successfully managed by cervical cerclage at 13 weeks' gestation, followed by clindamycin administration (600 mg/day for 7 days) and progesterone injections (250 mg/week). She gave birth to a healthy 3326-g male infant at 40 weeks and 1 day gestation after natural onset of labor. After delivery, the serum complement components were analyzed. C9 protein and activity were undetectable in the patient's serum. We suggest that an immunologic disorder such as C9 deficiency should be considered as a potential complication of undiagnosed recurrent miscarriages.
补体成分9（C9）缺乏相对常见，尤其是在日本。在此，我们报告一例27岁日本女性的病例，其产科病史包括三次孕中期流产（分别在妊娠22周、18周和21周）和一次早期自然流产。她的第五次妊娠在妊娠13周时通过宫颈环扎术成功处理，随后给予克林霉素（600mg/天，共7天）和黄体酮注射（250mg/周）。她在妊娠40周零1天自然发动分娩后，产下一名健康的3326克男婴。分娩后，对血清补体成分进行了分析。患者血清中未检测到C9蛋白和活性。我们建议，应将诸如C9缺乏等免疫紊乱视为未确诊的复发性流产的潜在并发症。
