School of Pharmacy and Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53705, United States.
Org Lett. 2012 Mar 16;14(6):1584-7. doi: 10.1021/ol300330t. Epub 2012 Mar 2.
Functionalized cyclopentenones were synthesized by a Rh-catalyzed carbonylation of 3-acyloxy-1,4-enynes, derived from alkynes and α,β-unsaturated aldehydes. The reaction involved a Saucy-Marbet 1,3-acyloxy migration of propargyl esters and a [4 + 1] cycloaddition of the resulting acyloxy substituted vinylallene with CO.
通过 Rh 催化的 3-酰氧基-1,4-烯炔的羰基化反应合成了功能化的环戊烯酮,该烯炔由炔烃和α,β-不饱和醛衍生而来。反应涉及炔丙酯的 Saucy-Marbet 1,3-酰氧基迁移和生成的取代酰氧基乙烯基烯与 CO 的[4+1]环加成。