School of Pharmacy, University of Wisconsin, Madison, WI 53705-2222 (USA).
Angew Chem Int Ed Engl. 2013 Dec 16;52(51):13601-5. doi: 10.1002/anie.201306919. Epub 2013 Oct 21.
Chiral bicycles: Enantioenriched bicyclo[5.3.0]decatrienes were prepared from readily available chiral 3-acyloxy-1,4-enynes (ACEs) for the first time. In most cases, the chirality of the ACEs could be transferred to the bicyclic products with high efficiency. Inversion of the configuration was observed, thus confirming the predictions of previous computational studies.
手性双环[5.3.0]癸三烯:首次从易得的手性 3-酰氧基-1,4-烯炔(ACE)制备出非对映富集的双环[5.3.0]癸三烯。在大多数情况下,ACE 的手性可以高效地转移到双环产物中。观察到构型的反转,从而证实了先前计算研究的预测。