Bashmakov Iu K, Briuzgina T S
Ukr Biokhim Zh (1978). 1990 Jul-Aug;62(4):106-9.
It is shown that the development of anaphylactoid shock in rats is connected with a decrease of the surface activity of alveolar surfactant and liberation of arachidonic acid from pulmonary surfactant phospholipids. Preventive injection of lipomodulators--A2 phospholipase inhibitor (mepacrine) or triglycecolipase inhibitor (propranolol)--to animals normalizes the level of lipids in the surfactant and blocks liberation of arachidonate and palmitate from surfactant phospholipids in an anaphylactoid shock.
结果表明，大鼠类过敏性休克的发展与肺泡表面活性物质表面活性降低以及花生四烯酸从肺表面活性物质磷脂中释放有关。对动物预防性注射脂质调节剂——A2磷脂酶抑制剂（米帕林）或甘油三酯脂肪酶抑制剂（普萘洛尔）——可使表面活性物质中的脂质水平正常化，并在类过敏性休克中阻止花生四烯酸和棕榈酸从表面活性物质磷脂中释放。
