Tugaĭ V A, Kurskiĭ M D, Diadiusha G P, Zakharchenko A N
Ukr Biokhim Zh (1978). 1990 Jul-Aug;62(4):67-71.
The initial rate of Ca2+ translocation in vesicular preparations of the sarcoplasmic reticulum membranes is shown to fall with a pH decrease to 6.0 or 5.0 and to rise with a pH change to 7.0 to 7.8 in respect to the initial 6.5. It is established that the Ca2+ sorption by the membranes or their fluidity make no essential contribution to the recorded changes of 45Ca2+ level in the membrane preparations. It is shown that the passive Ca2+ transport depends to a considerable extent on the concentration of a proton at the outer surface of the sarcoplasmic reticulum membrane: an excess of H+ inhibits the Ca2+ input and output, while a decrease of the proton concentration promotes an increase in the rate of these processes in the sarcoplasmic reticulum.
肌浆网膜囊泡制剂中Ca2+转运的初始速率显示，相对于初始pH 6.5，当pH降至6.0或5.0时下降，而当pH变为7.0至7.8时上升。已确定膜对Ca2+的吸附或其流动性对膜制剂中记录的45Ca2+水平变化没有实质性贡献。结果表明，被动Ca2+转运在很大程度上取决于肌浆网膜外表面质子的浓度：H+过量会抑制Ca2+的输入和输出，而质子浓度降低则会促进肌浆网中这些过程速率的增加。
