Burdon J G, Sinclair R A, Henderson M M
Chest. 1979 Sep;76(3):302-4. doi: 10.1378/chest.76.3.302.
Forty-six of 59 patients with small cell carcinoma of the lung who were treated with multiple drug chemotherapy and radiotherapy were subclassified according to the World Health Organization classification. Subtyping was not possible in the 13 other patients who were diagnosed on sputum cytology findings alone. There was no significant difference in extent of disease, response, duration of response to treatment, or median survival between the different subtypes. Two main difficulties arise in applying the subtyping classification. First, many tumors showed features of several histologic subtypes, implying the existence of a morphologic continuum within the general group of small cell anaplastic carcinomas. Second, tissue crushing artefact was common. Our results do not reveal any advantage in knowing the tumor subtype. It remains essential to differentiate small cell anaplastic carcinoma from other forms of lung carcinoma not responsive to chemotherapy.
59例接受多药化疗和放疗的肺小细胞癌患者中，46例根据世界卫生组织分类进行了亚型分类。另外13例仅根据痰细胞学检查结果确诊的患者无法进行亚型分类。不同亚型在疾病范围、反应、治疗反应持续时间或中位生存期方面没有显著差异。应用亚型分类存在两个主要困难。首先，许多肿瘤表现出几种组织学亚型的特征，这意味着在小细胞间变性癌的总体组内存在形态学连续性。其次，组织挤压假象很常见。我们的结果并未显示出了解肿瘤亚型有任何优势。将小细胞间变性癌与其他对化疗无反应的肺癌形式区分开来仍然至关重要。
