Hobbs G Aaron, Zhou Bingying, Cox Adrienne D, Campbell Sharon L
Department of Biochemistry and Biophysics; University of North Carolina; Chapel Hill, NC USA.
Department of Pharmacology; University of North Carolina; Chapel Hill, NC USA.
Small GTPases. 2014;5:e28579. doi: 10.4161/sgtp.28579. Epub 2014 May 8.
While numerous studies support regulation of Ras GTPases by reactive oxygen and nitrogen species, the Rho subfamily has received considerably less attention. Over the last few years, increasing evidence is emerging that supports the redox sensitivity of Rho GTPases. Moreover, as Rho GTPases regulate the cellular redox state by controlling enzymes that generate and convert reactive oxygen and nitrogen species, redox feedback loops likely exist. Here, we provide an overview of cellular oxidants, Rho GTPases, and their inter-dependence.
尽管众多研究支持活性氧和氮物种对Ras GTP酶的调节作用，但Rho亚家族受到的关注要少得多。在过去几年中，越来越多的证据表明Rho GTP酶具有氧化还原敏感性。此外，由于Rho GTP酶通过控制产生和转化活性氧和氮物种的酶来调节细胞氧化还原状态，因此可能存在氧化还原反馈回路。在这里，我们概述了细胞氧化剂、Rho GTP酶及其相互依赖性。
