Ozkaya Okan, Sezik Mekin, Kaya Hakan
Department of Obstetrics and Gynecology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
Med Sci Monit. 2008 Jan;14(1):CR47-51.
Malondialdehyde (MDA) is a marker of lipid peroxidation. Glutathione peroxidase (GPX) and superoxide dismutase (SOD) are the main enzymes responsible for the detoxification of superoxide anion. The aim was to assess whether serum MDA, erythrocyte GPX, and erythrocyte SOD levels altered during early spontaneous abortions presenting with vaginal bleeding.
MATERIAL/METHODS: A group of pregnant women at less than 8 weeks' gestation with spontaneous abortion and vaginal bleeding (n=23) and a control group of healthy pregnancies with similar characteristics (n=25) were included. Serum MDA levels, erythrocyte GPX, and SOD activities were determined and compared among the groups.
Characteristics, including maternal age, parity, gestational age, complete blood count values, serum total protein, serum albumin, and serum lipid profile, were similar across the groups. Spontaneous abortion prior to 8 weeks of gestation was associated with increased mean serum MDA levels and decreased mean erythrocyte SOD activity. Erythrocyte GPX values did not differ among the groups.
Increased lipid peroxidation and inhibition of SOD activity might be involved in the termination of spontaneous abortions and expulsion of fetoplacental material out of the uterine cavity.
丙二醛（MDA）是脂质过氧化的标志物。谷胱甘肽过氧化物酶（GPX）和超氧化物歧化酶（SOD）是负责超氧阴离子解毒的主要酶。目的是评估在早期自然流产伴阴道出血期间血清MDA、红细胞GPX和红细胞SOD水平是否发生改变。
材料/方法：纳入一组妊娠小于8周、自然流产伴阴道出血的孕妇（n = 23）和一组具有相似特征的健康妊娠对照组（n = 25）。测定并比较两组的血清MDA水平、红细胞GPX和SOD活性。
两组间的特征，包括产妇年龄、产次、孕周、全血细胞计数、血清总蛋白、血清白蛋白和血清脂质谱相似。妊娠8周前的自然流产与血清MDA平均水平升高和红细胞SOD平均活性降低有关。两组间红细胞GPX值无差异。
脂质过氧化增加和SOD活性受抑制可能参与自然流产的终止及胎儿胎盘物质从子宫腔排出。
