小非编码 RNA 调控乳腺肿瘤发生。
Small non-coding RNAs govern mammary gland tumorigenesis.
机构信息
Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
出版信息
J Mammary Gland Biol Neoplasia. 2012 Mar;17(1):59-64. doi: 10.1007/s10911-012-9246-4. Epub 2012 Mar 1.
Small non-coding RNAs include siRNA, miRNA, piRNA and snoRNA. The involvement of miRNAs in the regulation of mammary gland tumorigenesis has been widely studied while the role for other small non-coding RNAs remains unclear. Here we summarize the involvement of miRNA in breast cancer onset and progression through regulating the cell cycle and cellular proliferation. The regulation of breast cancer stem cells and tumor regeneration by miRNA is reviewed. In addition, the emerging evidence demonstrating the involvement of piRNA and snoRNA in breast cancer is briefly described.
小型非编码 RNA 包括 siRNA、miRNA、piRNA 和 snoRNA。miRNA 在调节乳腺肿瘤发生中的作用已被广泛研究，而其他小型非编码 RNA 的作用尚不清楚。本文总结了 miRNA 通过调节细胞周期和细胞增殖在乳腺癌发生和发展中的作用。综述了 miRNA 对乳腺癌干细胞和肿瘤再生的调控作用。此外，还简要描述了 piRNA 和 snoRNA 参与乳腺癌的新证据。
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