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2
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本文引用的文献

1
Suppression of progenitor differentiation requires the long noncoding RNA ANCR.祖细胞分化的抑制需要长非编码 RNA ANCR。
Genes Dev. 2012 Feb 15;26(4):338-43. doi: 10.1101/gad.182121.111. Epub 2012 Feb 2.
2
Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors.人类长非编码 RNA 通过与染色质修饰因子和转录因子的结合来促进多能性和神经元分化。
EMBO J. 2012 Feb 1;31(3):522-33. doi: 10.1038/emboj.2011.459. Epub 2011 Dec 23.
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Long noncoding RNA-mediated anti-apoptotic activity in murine erythroid terminal differentiation.长非编码 RNA 在鼠红细胞终末分化中的抗凋亡活性。
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The long noncoding RNA Vax2os1 controls the cell cycle progression of photoreceptor progenitors in the mouse retina.长链非编码 RNA Vax2os1 控制小鼠视网膜光感受器祖细胞的细胞周期进程。
RNA. 2012 Jan;18(1):111-23. doi: 10.1261/rna.029454.111. Epub 2011 Nov 29.
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Gracefully ageing at 50, X-chromosome inactivation becomes a paradigm for RNA and chromatin control.优雅地在 50 岁时衰老，X 染色体失活成为 RNA 和染色质控制的典范。
Nat Rev Mol Cell Biol. 2011 Nov 23;12(12):815-26. doi: 10.1038/nrm3231.
6
ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs.ncRNA- 和 Pc2 甲基化依赖性核结构间基因重定位介导基因激活程序。
Cell. 2011 Nov 11;147(4):773-88. doi: 10.1016/j.cell.2011.08.054.
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Chromosome silencing mechanisms in X-chromosome inactivation: unknown unknowns.X 染色体失活中的染色体沉默机制：未知的未知。
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8
RNA-directed epigenomic reprogramming: an emerging principle of a more targeted cancer therapy?RNA 导向的表观基因组重编程：一种更有针对性的癌症治疗新原则？
Genes Chromosomes Cancer. 2012 Feb;51(2):105-10. doi: 10.1002/gcc.20943. Epub 2011 Nov 1.
9
In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma.在致癌性 BRAF 诱导的黑色素瘤小鼠模型中体内鉴定肿瘤抑制性 PTEN ceRNAs。
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A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA.长非编码 RNA 通过作为竞争性内源 RNA 控制肌肉分化。
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非编码 RNA 参与乳腺发育和肿瘤发生：任重而道远。

Noncoding RNAs involved in mammary gland development and tumorigenesis: there's a long way to go.

机构信息

Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA.

出版信息

J Mammary Gland Biol Neoplasia. 2012 Mar;17(1):43-58. doi: 10.1007/s10911-012-9247-3. Epub 2012 Mar 9.

DOI:10.1007/s10911-012-9247-3
PMID:22402938
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3637027/
Abstract

The mammalian genome encodes thousands of noncoding RNAs. These noncoding transcripts are broadly categorized into short noncoding RNAs, such as microRNAs (miRNAs), and long noncoding RNAs (lncRNAs) of greater than 200 nt. While the role of miRNAs in development and cancer biology has been extensively studied, much less is known about the vast majority of noncoding transcripts represented by lncRNAs. LncRNAs are emerging as key regulators of developmental processes and as such, their frequent misregulation in tumorigenesis and disease in not unexpected. The role of lncRNAs in mammary gland development and breast cancer is just beginning to be elucidated. This review will discuss the role of lncRNAs in mammalian and mammary gland development. In addition, we will review the contributions of lncRNAs to the stepwise progression of tumorigenesis, highlighting the role of lncRNAs in breast cancer.

摘要

哺乳动物基因组编码了数千种非编码 RNA。这些非编码转录本广泛分为短非编码 RNA，如 microRNAs（miRNAs）和大于 200nt 的长非编码 RNA（lncRNAs）。虽然 miRNA 在发育和癌症生物学中的作用已经得到了广泛研究，但大多数由 lncRNAs 代表的非编码转录本的作用知之甚少。lncRNAs 正在成为发育过程的关键调节剂，因此，它们在肿瘤发生和疾病中的频繁失调并不出人意料。lncRNAs 在乳腺发育和乳腺癌中的作用才刚刚开始被阐明。这篇综述将讨论 lncRNAs 在哺乳动物和乳腺发育中的作用。此外，我们将回顾 lncRNAs 对肿瘤发生的逐步进展的贡献，强调 lncRNAs 在乳腺癌中的作用。