通过一系列连续的邻位铝化和亲电卤化反应，对 4-卤代苯甲醚进行区域选择性杂卤化。
Regioselective heterohalogenation of 4-halo-anisoles via a series of sequential ortho-aluminations and electrophilic halogenations.
机构信息
WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, UK.
出版信息
Chem Commun (Camb). 2012 May 16;48(39):4674-6. doi: 10.1039/c2cc30795b. Epub 2012 Mar 1.
PMID:22382935
Abstract
As the aluminate base [LiAl(TMP)(2)(iBu)(2)] 1 displays halogen tolerance towards substituted aromatics, 4-halo-anisoles have been ortho-aluminated and electrophilically quenched to form synthetically useful multi-heterohalogenated anisoles, with the Al intermediates along the route structurally defined.
摘要
由于铝酸盐碱 [LiAl(TMP)(2)(iBu)(2)] 1 对取代芳烃具有卤素耐受性，因此 4-卤代苯甲醚被邻位铝化并进行亲电淬灭，以形成具有合成用途的多卤代苯甲醚，其中 Al 中间体在路线中结构确定。
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