Pawlikowski M, Kunert-Radek J, Mróz-Wasilewska Z
Endokrinologie. 1979 Apr;73(2):186-90.
An influence of thyrotropin (TSH), dibutyryl cyclic AMP (dbcAMP), triiodothyronine (T3) and thyroxine (T4) on the mitotic incidence in the organ-cultured rat thyroid was studied. The study has revealed biphasic inhibitory and stimulatory effects of TSH on the thyroid mitotic activity. The inhibitory effect occurred 14 h after an exposure of the thyroid explants to TSH and was enhanced by T3. A similar inhibitory effect was observed after an exposure of the explants to dbcAMP. 24 h after the exposure of the thyroid explants to TSH a stimulatory effect on the mitotic incidence was observed. The latter effect was not reproduced by dbcAMP.
研究了促甲状腺激素（TSH）、二丁酰环磷腺苷（dbcAMP）、三碘甲状腺原氨酸（T3）和甲状腺素（T4）对器官培养的大鼠甲状腺有丝分裂发生率的影响。该研究揭示了TSH对甲状腺有丝分裂活性具有双相抑制和刺激作用。在甲状腺外植体暴露于TSH后14小时出现抑制作用，并被T3增强。在外植体暴露于dbcAMP后也观察到类似的抑制作用。在甲状腺外植体暴露于TSH后24小时，观察到对有丝分裂发生率的刺激作用。dbcAMP未重现后一种作用。
