Taylor M A, Hunt K R, Wilson C A, Baggott D G
Central Veterinary Laboratory, New Haw, Weybridge.
Vet Rec. 1990 Sep 22;127(12):302-3.
Two trials involving a total of 36 Dorset horn lambs were conducted to assess the anthelmintic efficacy of ivermectin against experimental infections of benzimidazole-resistant strains of Haemonchus contortus and Ostertagia circumcincta. Two resistant strains of each of the two species were used and in each trial the lambs were allocated to three groups. One group was given 200 micrograms ivermectin/kg bodyweight orally, the second group was given 5 mg oxfendazole/kg bodyweight orally and the third group remained untreated as controls. Fourteen days after treatment the lambs were necropsied. Ivermectin was found to be more than 99 per cent to 100 per cent effective against all four benzimidazole-resistant strains, whereas oxfendazole was 78.6 per cent and 83.8 per cent effective against the H contortus strains, and 25.6 per cent and 39.8 per cent effective against the O circumcincta strains.
进行了两项试验，共涉及36只多塞特角羔羊，以评估伊维菌素对苯并咪唑抗性捻转血矛线虫和环形奥斯特线虫实验感染的驱虫效果。使用了这两个物种的两种抗性菌株，在每项试验中，羔羊被分为三组。一组口服200微克伊维菌素/千克体重，第二组口服5毫克奥芬达唑/千克体重，第三组作为对照不进行治疗。治疗14天后对羔羊进行尸检。发现伊维菌素对所有四种苯并咪唑抗性菌株的有效性超过99%至100%，而奥芬达唑对捻转血矛线虫菌株的有效性分别为78.6%和83.8%，对环形奥斯特线虫菌株的有效性分别为25.6%和39.8%。
