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萨格勒布圣母医院血液学实验室凝血科的55年(1955年至2010年)历程及其创始人血液学家柳博米尔·波波维奇。

Fifty-five years (1955-2010) of the Coagulation Section at Laboratory of Hematology, Sestre milosrdnice University Hospital, and its founder, hematologist Ljubomir Popović.

作者信息

Stancić Vladimir, Stancić Nevenka, Vucelić Vesna, Lang Nada, Grbac Ljiljana

机构信息

Division of Hematology, University Department of Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.

出版信息

Acta Clin Croat. 2011 Sep;50(3):385-94.

PMID:22384775
Abstract

The Coagulation Section at Laboratory of Hematology, Sestre milosrdnice University Hospital, Zagreb, was founded in 1955 by Ljubomir Popović, hematologist and assistant at School of Medicine, University of Zagreb, in cooperation with hard-working laboratory technicians. Apart from papers on hematologic neoplasms, plasmacytoma and lymphoma, Ljubomir Popović published a number of papers in the field of anticoagulant therapy with heparin and oral anticoagulants, some of which are also in use today. After Ljubomir Popović left the Hospital in 1964, the Laboratory was run by Professor Nedjeljko Milić, head of the newly founded Division of Hematology. In 1968, the management of the Laboratory of Hematology was taken over by Biserka Raić, MS, medical biochemist, until her retirement in 2007. Great development in morphological and cytometric studies of blood and blood cells has been paralleled by continuous progress and almost dominating activities in the diagnosis of hemostasis disorders. In the 1970s, Marko Koprcina, hematologist, and Biserka Raić introduced the then latest tests in practice at all Hospital departments. In that golden age of the Coagulation Section, M. Koprcina, B. Raić and their associates transferred their knowledge to all colleagues in the Hospital. Through that collaboration, high standards in the diagnosis of hemostasis disorders were achieved, from which the currently high level of clinical knowledge about coagulation disorders and their treatment has derived, making Sestre milosrdnice University Hospital one of the leading hospitals in this field in the country. By describing development of the Coagulation Section and the life of its founder Ljubomir Popović, the authors tried to provide an answer to the following question: can today's clinicians still have a deciding role in laboratory development, considering that assessments of different phenomena are always initiated by an interested clinician who is trying to interpret and understand the nature of the disorder? This means that the clinician's place may still be in the laboratory, or else, it will become clear that the laboratory, as well as knowledge in general, has undergone such an expansion that the clinician is no longer able to run it by himself. It is our belief that the answer will assert itself through the survey of the history of the Coagulation Section at Laboratory of Hematology, Division of Hematology, and the lives of its founders and beneficiaries.

摘要

萨格勒布塞斯特米洛什尔尼察大学医院血液学实验室的凝血科由萨格勒布大学医学院血液学家兼助理卢博米尔·波波维奇于1955年创立,他与勤奋的实验室技术人员合作。除了关于血液系统肿瘤、浆细胞瘤和淋巴瘤的论文外,卢博米尔·波波维奇还在肝素和口服抗凝剂的抗凝治疗领域发表了多篇论文,其中一些至今仍在使用。1964年卢博米尔·波波维奇离开医院后,该实验室由新成立的血液学部门负责人内德耶尔科·米利奇教授管理。1968年,血液学实验室的管理工作由医学生物化学家比塞卡·拉伊奇硕士接管,直至她2007年退休。血液和血细胞形态学及细胞计量学研究的巨大发展与止血障碍诊断方面的持续进步以及几乎占据主导地位的活动并行。20世纪70年代,血液学家马尔科·科普尔契纳和比塞卡·拉伊奇在医院所有科室引入了当时最新的检测方法。在凝血科的那个黄金时代,M. 科普尔契纳、B. 拉伊奇及其同事将他们的知识传授给了医院的所有同事。通过这种合作,在止血障碍诊断方面达到了高标准,当前关于凝血障碍及其治疗的高水平临床知识即源于此,这使萨格勒布塞斯特米洛什尔尼察大学医院成为该国该领域的领先医院之一。通过描述凝血科的发展及其创始人卢博米尔·波波维奇的生平,作者试图回答以下问题:考虑到对不同现象的评估总是由试图解释和理解疾病本质的感兴趣的临床医生发起,当今的临床医生在实验室发展中是否仍能发挥决定性作用?这意味着临床医生的位置可能仍在实验室,否则,将会清楚地看到,实验室以及一般知识已经经历了如此大的扩展,以至于临床医生不再能够独自管理它。我们相信,答案将通过对血液学实验室凝血科的历史、血液学部门及其创始人与受益者的生活进行考察而显现出来。

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