Neuroimmunology Group, Centre for Neuroscience and Trauma, Flow Cytometry Group, Blizard Institute, Queen Mary University of London, Barts and The London, London, UK.
Clin Exp Immunol. 2012 Apr;168(1):52-7. doi: 10.1111/j.1365-2249.2011.04544.x.
Death rules our lives. In this short paper, we summarize new insights into molecular mechanisms of neurodegeneration. Here we review the most important processes of cell death: apoptosis and oncosis. We focus on autophagy, which is pivotal for neuronal homeostasis, in the context of neurodegeneration, infection and immunity. Its dysfunction has been linked to several neurodegenerative diseases such as Parkinson's, Huntington's and Alzheimer's diseases. Our understanding is still incomplete, but may highlight attractive new avenues for the development of treatment strategies to combat neurodegenerative diseases.
死亡主宰着我们的生命。在这篇短文中，我们总结了有关神经退行性变分子机制的新见解。在这里，我们回顾了细胞死亡的最重要过程：凋亡和胀亡。我们专注于自噬，它在神经退行性变、感染和免疫的背景下对神经元稳态至关重要。其功能障碍与帕金森病、亨廷顿病和阿尔茨海默病等几种神经退行性疾病有关。我们的理解仍然不完整，但可能突出了开发治疗策略来对抗神经退行性疾病的有吸引力的新途径。
