Radical Therapeutix, Inc., Solana Beach, CA, USA.
Autophagy. 2011 Apr;7(4):434-5. doi: 10.4161/auto.7.4.14442. Epub 2011 Apr 1.
Interventions that reduce infarct size in animal models have largely failed to improve outcome in patients suffering acute myocardial infarction (MI), or 'heart attack'. Our group recently reported a reduction of infarct size by chloramphenicol treatment in a porcine in vivo model of acute MI, through a mechanism involving the induction of autophagy. Since 2005 several studies have implicated autophagy as a target for cardioprotection.
干预措施可减少动物模型中的梗塞面积，但在急性心肌梗死（MI）或“心脏病发作”患者中，这些措施在改善患者预后方面基本上都没有效果。我们的研究小组最近报告称，在猪急性 MI 的体内模型中，通过诱导自噬，氯霉素治疗可减少梗塞面积。自 2005 年以来，已有多项研究表明自噬是心脏保护的一个靶点。
