Katovich M J, Barney C C, Fregly M J, McCaa R E
Eur J Pharmacol. 1979 Jun;56(1-2):123-30. doi: 10.1016/0014-2999(79)90441-2.
The effect of acute administration of SQ 14,225, a new angiotensin converting enzyme inhibitor, on the drinking response of female rats administered either isoprenaline, angiotensin I, or angiotensin II was studied during 2 h after treatment. Administration of isoprenaline (25 micrograms/kg body wt) was accompanied by a significant increase in water intake when compared with saline-treated controls. Acute administration of a constant dose of isoprenaline (25 micrograms/kg body wt) and increasing doses of SQ 14,225 (5--50 mg/kg) was accompanied by a dose-related, linear decrease in water intake. Acute administration of either angiotensin I or angiotensin II (200 micrograms/kg body wt) was accompanied by a significant increase in water intake. The dipsogenic response to angiotensin II was not affected by acute administration of 35 mg SQ 14,225/kg body wt. However, at the same dose of SQ 14,225, angiotensin I-induced thirst was attenuated. Since isoprenaline-induced and angiotensin I-induced, but not angiotensin II-induced, thirsts are blocked by SQ 14,225, the results suggest that isoprenaline-induced thirst is mediated by way of the renin--angiotensin system.
研究了新型血管紧张素转换酶抑制剂SQ 14,225急性给药对用异丙肾上腺素、血管紧张素I或血管紧张素II处理的雌性大鼠在处理后2小时内饮水反应的影响。与用生理盐水处理的对照组相比，给予异丙肾上腺素（25微克/千克体重）会伴随饮水量显著增加。急性给予恒定剂量的异丙肾上腺素（25微克/千克体重）和递增剂量的SQ 14,225（5 - 50毫克/千克）会伴随饮水量呈剂量相关的线性下降。急性给予血管紧张素I或血管紧张素II（200微克/千克体重）会伴随饮水量显著增加。对血管紧张素II的致渴反应不受急性给予35毫克SQ 14,225/千克体重的影响。然而，在相同剂量的SQ 14,225下，血管紧张素I诱导的口渴会减弱。由于异丙肾上腺素诱导的口渴和血管紧张素I诱导的口渴（而非血管紧张素II诱导的口渴）会被SQ 14,225阻断，结果表明异丙肾上腺素诱导的口渴是通过肾素 - 血管紧张素系统介导的。
