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中枢血管紧张素转换酶阻断与口渴。

Central angiotensin converting enzyme-blockade and thirst.

作者信息

Saad W A, Luiz A C, Camargo L A, Menani J V, Renzi A, Silveira J E

机构信息

Departamento de Fisiologia, Faculdade de Odontologia, Universidade Estadual Paulista, Araraquara, SP, Brasil.

出版信息

Braz J Med Biol Res. 1993 Sep;26(9):999-1007.

PMID:8298535
Abstract
  1. The effect of lisinopril, a potent inhibitor of angiotensin converting enzyme (ACE), injected into the medial preoptic area (MPOA) on water intake was investigated in male Holtzman rats (200-250 g). 2. Injection of lisinopril (2 micrograms/microliters) into the MPOA abolished the water intake induced by subcutaneous (sc) injection of isoprenaline (100%) and water deprivation (90%) and drastically reduced the water intake induced by sc injection of polyethyleneglycol (60%). A small reduction of water intake induced by lisinopril was also observed 90 and 120 min after sc hypertonic saline (N = 10 for each group). 3. These results suggest that central ACE activation, particularly in the MPOA, plays an important role in the dipsogenic responses induced by the agents studied.
摘要
  1. 研究了向雄性霍尔兹曼大鼠（200 - 250克）内侧视前区（MPOA）注射血管紧张素转换酶（ACE）强效抑制剂赖诺普利对水摄入量的影响。2. 向MPOA注射赖诺普利（2微克/微升）可消除皮下注射异丙肾上腺素（100%）和禁水（90%）诱导的水摄入，并显著减少皮下注射聚乙二醇（60%）诱导的水摄入。皮下注射高渗盐水后90分钟和120分钟，也观察到赖诺普利引起的水摄入量有小幅减少（每组N = 10）。3. 这些结果表明，中枢ACE激活，特别是在MPOA中，在所研究药物诱导的饮水反应中起重要作用。

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