中枢血管紧张素转换酶阻断与口渴。

Central angiotensin converting enzyme-blockade and thirst.

Saad W A, Luiz A C, Camargo L A, Menani J V, Renzi A, Silveira J E

Departamento de Fisiologia, Faculdade de Odontologia, Universidade Estadual Paulista, Araraquara, SP, Brasil.

Braz J Med Biol Res. 1993 Sep;26(9):999-1007.

Abstract

The effect of lisinopril, a potent inhibitor of angiotensin converting enzyme (ACE), injected into the medial preoptic area (MPOA) on water intake was investigated in male Holtzman rats (200-250 g). 2. Injection of lisinopril (2 micrograms/microliters) into the MPOA abolished the water intake induced by subcutaneous (sc) injection of isoprenaline (100%) and water deprivation (90%) and drastically reduced the water intake induced by sc injection of polyethyleneglycol (60%). A small reduction of water intake induced by lisinopril was also observed 90 and 120 min after sc hypertonic saline (N = 10 for each group). 3. These results suggest that central ACE activation, particularly in the MPOA, plays an important role in the dipsogenic responses induced by the agents studied.

摘要

研究了向雄性霍尔兹曼大鼠（200 - 250克）内侧视前区（MPOA）注射血管紧张素转换酶（ACE）强效抑制剂赖诺普利对水摄入量的影响。2. 向MPOA注射赖诺普利（2微克/微升）可消除皮下注射异丙肾上腺素（100%）和禁水（90%）诱导的水摄入，并显著减少皮下注射聚乙二醇（60%）诱导的水摄入。皮下注射高渗盐水后90分钟和120分钟，也观察到赖诺普利引起的水摄入量有小幅减少（每组N = 10）。3. 这些结果表明，中枢ACE激活，特别是在MPOA中，在所研究药物诱导的饮水反应中起重要作用。