Lehr D, Goldman H W, Casner P
Science. 1973 Dec 7;182(4116):1031-4. doi: 10.1126/science.182.4116.1031.
A competitive angiotensin converting enzyme antagonist SQ 20, 881 (SQ), was used to examine the role of the renin-angiotensin system in putative renin-dependent thirst in the albino rat. Significant enhancement of "renin-dependent" as well as renin-independent drinking was observed in the presence of peripheral SQ. Intraventricular SQ obviated this enhancement of drinking but did not affect the water intake caused by the original stimulus itself, whereas it sharply reduced drinking evoked by peripheral renin in nephrectomized rats. Prior renin depletion likewise had no influence on so-called renin-dependent thirst.
一种竞争性血管紧张素转换酶拮抗剂SQ 20881（SQ）被用于研究肾素-血管紧张素系统在白化大鼠假定的肾素依赖性口渴中的作用。在外周给予SQ的情况下，观察到“肾素依赖性”以及非肾素依赖性饮水均显著增强。脑室内注射SQ消除了这种饮水增强，但不影响原始刺激本身引起的水摄入，而它能显著减少肾切除大鼠外周肾素引起的饮水。预先进行肾素耗竭同样对所谓的肾素依赖性口渴没有影响。
