Borda E, Sauvage J, Sterin-Borda L, Gimeno M F, Gimeno A L
Eur J Pharmacol. 1979 Jun;56(1-2):61-7. doi: 10.1016/0014-2999(79)90433-3.
Cumulative log dose-response curves of soterenol, isoproterenol, phenylephrine and norepinephrine on isolated pregnant rat uterus at different days of gestation, were investigated. Soterenol produced a sustained inhibition of spontaneous motility during the whole pregnancy and this effect was blocked by butoxamine. The affinity of myometrium for the beta 2-adrenoceptor agonist was parallel to the concentration of progesterone in plasma during pregnancy. Isoproterenol, norepinephrine and phenylephrine caused dual, alpha- and beta-mediated responses, their relative dominance varied with the concentration and the days of pregnancy, alpha-Adrenoceptor effects of the amines coincided with increased plasma concentrations of estrogens, whereas beta ones were in parallel with the increment of plasma progesterone. It is concluded that: (a) there exist in the pregnant rat uterus beta 2-receptor-mediated responses influenced by the length of gestation; and (b) the concentration-pregnancy-dependent biphasic actions of isoproterenol, norepinephrine or phenylephrine suggest that their variable hormone-modulated ability interacts with both alpha- and beta-adrenoceptive uterine sites.
研究了索特雷诺、异丙肾上腺素、去氧肾上腺素和去甲肾上腺素对不同妊娠天数的离体妊娠大鼠子宫的累积对数剂量-反应曲线。索特雷诺在整个妊娠期对自发运动产生持续抑制作用，且该作用被布托沙明阻断。子宫肌层对β2-肾上腺素能受体激动剂的亲和力与妊娠期血浆中孕酮浓度平行。异丙肾上腺素、去甲肾上腺素和去氧肾上腺素引起α和β介导的双重反应，它们的相对优势随浓度和妊娠天数而变化，胺类的α-肾上腺素能受体效应与血浆雌激素浓度升高一致，而β效应与血浆孕酮的增加平行。得出以下结论：(a) 妊娠大鼠子宫中存在受妊娠时长影响的β2受体介导的反应；(b) 异丙肾上腺素、去甲肾上腺素或去氧肾上腺素的浓度-妊娠依赖性双相作用表明，它们可变的激素调节能力与子宫的α和β肾上腺素能受体部位相互作用。
