神经内分泌细胞内游离 Ca2+与环 AMP 的相互作用。

Interactions between intracellular free Ca2+ and cyclic AMP in neuroendocrine cells.

机构信息

Division of Preclinical Research, EGIS Pharmaceuticals PLC, Hungary.

出版信息

Cell Calcium. 2012 Mar-Apr;51(3-4):260-6. doi: 10.1016/j.ceca.2011.12.013. Epub 2012 Mar 3.

DOI:10.1016/j.ceca.2011.12.013

Abstract

Calcium ions and cyclic adenosine monophosphate (cAMP) are virtually ubiquitous intracellular signaling molecules in mammalian cells. This paper will focus on the cross-talk between Ca(2+) and cAMP mobilizing signaling pathways and summarize the underlying molecular mechanisms. Subsequently, workings of adenohypophyseal corticotrope cells will be reviewed to highlight the physiological relevance of a Ca(2+) cAMP interactions in neuroendocrinology.

摘要

钙离子和环腺苷酸（cAMP）是哺乳动物细胞中几乎无处不在的细胞内信号分子。本文将重点讨论 Ca(2+) 和 cAMP 动员信号通路之间的串扰，并总结潜在的分子机制。随后，将回顾腺垂体促皮质细胞的工作原理，以突出 Ca(2+) cAMP 相互作用在神经内分泌学中的生理相关性。