Ghrelin Research Project, Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto University School of Medicine, Kyoto 606-8507, Japan.
Eur J Intern Med. 2012 Apr;23(3):197-202. doi: 10.1016/j.ejim.2011.12.001. Epub 2011 Dec 30.
Ghrelin, a natural ligand for the growth hormone (GH)-secretagogue receptor (GHS-R), is now known to play a role in a number of different physiological processes. For example, ghrelin increases GH secretion, feeding, and body weight when administered centrally or peripherally. These unique effects of ghrelin should be invaluable for the development of novel treatments and disease diagnostic techniques. Clinical trials have already been performed to assess the utility of ghrelin for the treatment of several disorders including anorexia, cachexia, and GH-related disorders. This review summarizes the recent advances in this area of research.
胃饥饿素是生长激素（GH）促分泌素受体（GHS-R）的天然配体，现在已知它在许多不同的生理过程中发挥作用。例如，胃饥饿素在中枢或外周给药时可增加 GH 的分泌、摄食和体重。胃饥饿素的这些独特作用对于开发新的治疗方法和疾病诊断技术应该是非常有价值的。已经进行了临床试验来评估胃饥饿素治疗包括厌食症、恶病质和 GH 相关疾病在内的几种疾病的效用。这篇综述总结了这一研究领域的最新进展。
