Kamiji Mayra M, Inui Akio
Department of Gastroenterology, Faculty of Medicine, University of São Paulo, Ribeirão Preto, Brazil.
Curr Opin Clin Nutr Metab Care. 2008 Jul;11(4):443-51. doi: 10.1097/MCO.0b013e328303dee4.
The purpose of this review is to summarize recent studies that investigated the role of ghrelin and ghrelin analogs in wasting conditions.
Numerous studies have demonstrated potential beneficial effects exerted by ghrelin in a number of diseases associated with wasting. Besides ghrelin's orexigenic effect, anabolic as well as anti-inflammatory activity mediated by ghrelin have been investigated in wasting conditions such as cancer, diabetes mellitus, malabsorptive diseases, chronic obstructive pulmonary disease, anorexia nervosa, renal failure, liver failure, and chronic heart failure. Encouraging results have been obtained from experimental studies and a few clinical trials using subcutaneous administration of ghrelin and ghrelin agonists in cachexia. In-vitro studies have shown ghrelin and des-acyl ghrelin biological activities on proliferation of tumor cells and abnormal tissues.
The recent studies support the possible positive effects of ghrelin in therapeutic approaches and adjunct treatment of a number of diseases associated with wasting. Utilization of agonists of the ghrelin receptor growth hormone secretagogue-1a is a promising approach for clinical use. Randomized and placebo-controlled studies, including large number of patients are further required.
本综述旨在总结近期研究，这些研究探讨了胃饥饿素及其类似物在消瘦性疾病中的作用。
大量研究表明，胃饥饿素在多种与消瘦相关的疾病中具有潜在的有益作用。除了胃饥饿素的促食欲作用外，在癌症、糖尿病、吸收不良性疾病、慢性阻塞性肺疾病、神经性厌食症、肾衰竭、肝衰竭和慢性心力衰竭等消瘦性疾病中，还对胃饥饿素介导的合成代谢以及抗炎活性进行了研究。在恶病质中，通过皮下注射胃饥饿素和胃饥饿素激动剂的实验研究和一些临床试验已取得了令人鼓舞的结果。体外研究表明，胃饥饿素和去酰基胃饥饿素对肿瘤细胞和异常组织的增殖具有生物学活性。
近期研究支持胃饥饿素在多种与消瘦相关疾病的治疗方法和辅助治疗中可能具有的积极作用。使用胃饥饿素受体生长激素促分泌素-1a激动剂是一种有前景的临床应用方法。还需要进一步开展包括大量患者的随机和安慰剂对照研究。
