Faculty of Medicine, UNAM, Coyoacán DF 04510, Mexico.
Nutr Metab Cardiovasc Dis. 2013 Jun;23(6):536-42. doi: 10.1016/j.numecd.2011.10.008. Epub 2012 Mar 2.
To determine if a single oral dose of fructose to rats reproduces some features of metabolic syndrome observed after chronic administration and if so, to investigate its mechanisms.
Systolic blood pressure was measured in rats before and after oral administration of fructose, and in animals pretreated with lipoic acid, methyldopa, losartan or streptozotocin. In other rats, glucose, insulin, uric acid, and insulin sensitivity index, were determined before and after fructose or lipoic acid plus fructose. Glutathione was measured in liver before and after fructose administration. In aortic rings from other rats, incubation with mannitol, fructose, or fructose plus lipoic acid was evaluated on the relaxation by acetylcholine. Fructose produced a moderate increase in blood pressure, which was prevented by lipoic acid or streptozotocin. Methyldopa and losartan decreased the pressor response minimally. Fructose increased oxidized glutathione, plasma glucose, insulin and uric acid, and diminished the insulin sensitivity index, and the reduced glutathione. Lipoic acid prevented hyperglycemia and hyperuricemia, and improved the insulin sensitivity index. Finally, endothelial dysfunction was prevented by lipoic acid.
A single dose of fructose reproduces some of the features of metabolic syndrome, most changes were caused by oxidative stress and insulin resistance.
确定大鼠单次口服果糖是否会复制慢性给予果糖后观察到的代谢综合征的某些特征，如果是这样，那么研究其机制。
在大鼠口服果糖前后测量其收缩压，并在预先用硫辛酸、甲多巴、氯沙坦或链脲佐菌素处理的动物中进行测量。在其他大鼠中，在给予果糖或硫辛酸加果糖前后，测定血糖、胰岛素、尿酸和胰岛素敏感性指数。在给予果糖前后测量肝脏中的谷胱甘肽。在其他大鼠的主动脉环中，评估甘露醇、果糖或果糖加硫辛酸对乙酰胆碱松弛的影响。果糖会导致血压中度升高，硫辛酸或链脲佐菌素可预防这种升高。甲多巴和氯沙坦可使升压反应最小程度降低。果糖会增加氧化型谷胱甘肽、血浆葡萄糖、胰岛素和尿酸，并降低胰岛素敏感性指数和还原型谷胱甘肽。硫辛酸可防止高血糖和高尿酸血症，并改善胰岛素敏感性指数。最后，硫辛酸可预防内皮功能障碍。
单次剂量的果糖可复制代谢综合征的某些特征，大多数变化是由氧化应激和胰岛素抵抗引起的。
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