Department of Psychiatry, Sestre milosrdnice University Hospital, Zagreb, Croatia.
Psychiatry Res. 2012 Jun 30;198(1):74-80. doi: 10.1016/j.psychres.2011.12.007. Epub 2012 Mar 3.
The aim of the present study was to explore possible differences between serum C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and cortisol concentration in patients with major depressive disorder (MDD) with melancholic features, and MDD with atypical features. As secondary aim, we investigated possible associations with clinical features such as suicidal ideation, number of episodes, duration of depression and symptomatology severity. We included 55 MDD patients (32 with melancholic features and 23 with atypical features) and 18 healthy controls. When compared to healthy controls, MDD with melancholic or atypical features showed higher CRP and IL-6, but not TNF-α. Cortisol concentration was higher in MDD with melancholic type, in comparison to the atypical type of MDD or controls. A positive correlation was found between the severity of depressive symptoms, concentrations of IL-6 and cortisol in the MDD group with melancholic features, while a negative correlation was observed between IL-6 and CRP in the MDD group with atypical feature. Also, in the MDD group with atypical features, there was a correlation between the severity of anxiety symptoms based on the Hamilton Rating Scale for Anxiety (HARS), concentration of CRP, and the duration of symptoms. In conclusion, we observed several differences in serum CRP, IL-6, and cortisol concentrations in MDD patients considering clinical features as well.
本研究旨在探讨具有忧郁特征和非典型特征的重度抑郁症（MDD）患者与健康对照组之间血清 C 反应蛋白（CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和皮质醇浓度的可能差异。作为次要目标，我们调查了与自杀意念、发作次数、抑郁持续时间和症状严重程度等临床特征的可能相关性。我们纳入了 55 名 MDD 患者（32 名具有忧郁特征，23 名具有非典型特征）和 18 名健康对照组。与健康对照组相比，具有忧郁或非典型特征的 MDD 患者的 CRP 和 IL-6 水平较高，但 TNF-α 水平没有差异。具有忧郁型 MDD 的皮质醇浓度高于具有非典型型 MDD 或对照组。在具有忧郁特征的 MDD 组中，抑郁症状严重程度、IL-6 和皮质醇浓度之间存在正相关，而在具有非典型特征的 MDD 组中，IL-6 和 CRP 之间存在负相关。此外，在具有非典型特征的 MDD 组中，汉密尔顿焦虑量表（HARS）评估的焦虑症状严重程度、CRP 浓度和症状持续时间之间存在相关性。总之，我们观察到考虑到临床特征，MDD 患者的血清 CRP、IL-6 和皮质醇浓度存在一些差异。
