Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany.
Vascul Pharmacol. 2012 May-Jun;56(5-6):210-5. doi: 10.1016/j.vph.2012.02.009. Epub 2012 Feb 22.
The Ca(2+)-activated proteases or calpains, play a crucial role in a spectrum of physiological processes such as cytoskeletal remodeling, cellular signaling, cell migration, apoptosis, cell survival and platelet activation, by the proteolytic cleavage of target proteins. Rather than eliciting protein degradation the calpains are responsible for their modification (e.g. activation, inhibition or altered sensitivity to intracellular signals) and therefore make a significant impact on intracellular signaling. Maintained calpain activation is known to be associated with disease development and in platelet calpains are involved in both physiological platelet activation as well as pathological platelet hyper-activation.
钙激活蛋白酶或钙蛋白酶在一系列生理过程中发挥着关键作用，如细胞骨架重塑、细胞信号转导、细胞迁移、细胞凋亡、细胞存活和血小板激活等，通过对靶蛋白的蛋白水解切割来实现。钙蛋白酶不是引起蛋白质降解，而是负责其修饰（例如激活、抑制或改变对细胞内信号的敏感性），因此对细胞内信号转导有重要影响。已知持续的钙蛋白酶激活与疾病的发展有关，而血小板钙蛋白酶参与了生理血小板激活以及病理性血小板过度激活。
