Department of Obstetrics and Gynaecology, University Medical Center Groningen, P.O. Box 30001, Hanzeplein 1, 9700 RB Groningen, The Netherlands.
Placenta. 2012 May;33(5):453-5. doi: 10.1016/j.placenta.2012.02.010. Epub 2012 Mar 3.
During pregnancy the maternal immune system has to coordinate uterine spiral-artery remodelling, trophoblast invasion, and acceptance of the semi-allogenic fetus simultaneously. As dysregulation of the immune system is associated with adverse pregnancy outcomes, we analysed first-trimester deciduas of pregnancies for immune parameters in later complicated pregnancies. Higher IL6 and macrophage mRNA expression, and lower ratios of regulatory macrophages were found in first-trimester deciduas of pregnancies later complicated with pregnancy-induced hypertension. Lower Gata3 (Th2) mRNA expression was found in deciduas of pregnancies with later foetal growth restriction. Our results suggest that adverse pregnancy outcomes are associated with immunological disturbances in first-trimester deciduas.
在妊娠期间，母体免疫系统必须同时协调子宫螺旋动脉重塑、滋养层浸润和对半同种异体胎儿的接受。由于免疫系统的失调与不良的妊娠结局有关，我们分析了妊娠早期蜕膜中的免疫参数，以了解后期复杂妊娠的情况。在妊娠晚期并发妊娠高血压的患者中，妊娠早期蜕膜中发现白细胞介素 6（IL6）和巨噬细胞 mRNA 表达增加，调节性巨噬细胞比例降低。在妊娠晚期胎儿生长受限的患者中，发现 Gata3（Th2）mRNA 表达降低。我们的研究结果表明，不良的妊娠结局与妊娠早期蜕膜中的免疫紊乱有关。
