抗CV2/CRMP5抗体相关神经系统副肿瘤综合征揭示小细胞肺癌。肺癌治疗的有效性
[Neurologic paraneoplastic syndrome with anti-CV2/CRMP5 antibodies revealing a small cell lung cancer. Effectiveness of the lung cancer treatment].
作者信息
Rosencher L, Maisonobe T, Lavole A, Milleron B, Ferroir J-P
机构信息
Service de pneumologie, hôpital Tenon, 4, rue de la Chine, 75970 Paris, France.
出版信息
Rev Neurol (Paris). 2012 Apr;168(4):371-4. doi: 10.1016/j.neurol.2011.07.016. Epub 2012 Mar 3.
INTRODUCTION
Paraneoplastic neurological syndrome associated with anti-CV2/CRMP5 antibodies are rare. Various clinical manifestations can occur, cerebellar ataxia, polyneuropathy, optic neuritis with NORB or uveitis. Small cell lung carcinoma is generally responsible.
CASE REPORT
We report the case of a 64-year-old man who developed visual symptoms with papilledema, cerebellar signs, polyneuropathy confirmed with a neurophysiological studies. Anti-CV2/CRMP5 antibodies were present. A small cell lung carcinoma was responsible for this paraneoplastic syndrome revealing the cancer. The paraneoplastic syndrome improved with radio chemotherapy of the cancer alone.
CONCLUSION
A paraneoplastic neurological syndrome must be evoked in case of an atypic neurological syndrome. This diagnostic can be confirmed by the presence of anti-neuronal antibodies. In this case, a small cells cancer of the lung must be research.
引言
与抗CV2/CRMP5抗体相关的副肿瘤性神经综合征较为罕见。可出现多种临床表现，如小脑共济失调、多发性神经病、伴有NORB的视神经炎或葡萄膜炎。通常由小细胞肺癌引起。
病例报告
我们报告一例64岁男性，出现视乳头水肿的视觉症状、小脑体征、经神经生理学研究确诊的多发性神经病。存在抗CV2/CRMP5抗体。小细胞肺癌导致了这种副肿瘤综合征并揭示了癌症。仅通过癌症的放化疗，副肿瘤综合征就得到了改善。
结论
在出现非典型神经综合征的情况下，必须考虑副肿瘤性神经综合征。这种诊断可通过抗神经元抗体的存在来证实。在这种情况下，必须排查肺小细胞癌。
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