Rosencher L, Maisonobe T, Lavole A, Milleron B, Ferroir J-P
Service de pneumologie, hôpital Tenon, 4, rue de la Chine, 75970 Paris, France.
Rev Neurol (Paris). 2012 Apr;168(4):371-4. doi: 10.1016/j.neurol.2011.07.016. Epub 2012 Mar 3.
Paraneoplastic neurological syndrome associated with anti-CV2/CRMP5 antibodies are rare. Various clinical manifestations can occur, cerebellar ataxia, polyneuropathy, optic neuritis with NORB or uveitis. Small cell lung carcinoma is generally responsible.
We report the case of a 64-year-old man who developed visual symptoms with papilledema, cerebellar signs, polyneuropathy confirmed with a neurophysiological studies. Anti-CV2/CRMP5 antibodies were present. A small cell lung carcinoma was responsible for this paraneoplastic syndrome revealing the cancer. The paraneoplastic syndrome improved with radio chemotherapy of the cancer alone.
A paraneoplastic neurological syndrome must be evoked in case of an atypic neurological syndrome. This diagnostic can be confirmed by the presence of anti-neuronal antibodies. In this case, a small cells cancer of the lung must be research.
与抗CV2/CRMP5抗体相关的副肿瘤性神经综合征较为罕见。可出现多种临床表现，如小脑共济失调、多发性神经病、伴有NORB的视神经炎或葡萄膜炎。通常由小细胞肺癌引起。
我们报告一例64岁男性，出现视乳头水肿的视觉症状、小脑体征、经神经生理学研究确诊的多发性神经病。存在抗CV2/CRMP5抗体。小细胞肺癌导致了这种副肿瘤综合征并揭示了癌症。仅通过癌症的放化疗，副肿瘤综合征就得到了改善。
在出现非典型神经综合征的情况下，必须考虑副肿瘤性神经综合征。这种诊断可通过抗神经元抗体的存在来证实。在这种情况下，必须排查肺小细胞癌。
