Departamento de Infectómica y Patogénesis Molecular, México, DF, Mexico.
Antiviral Res. 2012 Apr;94(1):57-61. doi: 10.1016/j.antiviral.2012.02.006. Epub 2012 Feb 22.
Dengue is the most important mosquito-borne viral infection in humans. Recent evidence suggests that vitamin D influences virus replication. In this work, the effect of vitamin D treatment on dengue virus infection in human hepatic Huh-7 cells and on virus infection and cytokine production in the human monocytic U937 cells was evaluated. Exposure to 1α,25-dihydroxy-vitamin D3, resulted in a significant reduction in the number of infected cells, in conditions where cell viability was not affected. Viral replication in monocytic cells was more susceptible to vitamin D3 than replication in the hepatic cells. Moreover, vitamin D3 significantly reduced the levels of proinflammatory cytokines (TNF-α, IL-6, IL-12p70 and IL-1β) produced by infected U937 cells. These results suggest that vitamin D3 may represent a potentially useful antiviral compound.
登革热是人类最重要的由蚊子传播的病毒感染。最近的证据表明，维生素 D 会影响病毒复制。在这项工作中，评估了维生素 D 治疗对人肝 Huh-7 细胞中登革热病毒感染以及对人单核细胞 U937 细胞中病毒感染和细胞因子产生的影响。在不影响细胞活力的情况下，暴露于 1α,25-二羟维生素 D3 会导致感染细胞数量明显减少。单核细胞中的病毒复制比肝细胞中的复制更容易受到维生素 D3 的影响。此外，维生素 D3 还显著降低了受感染的 U937 细胞产生的促炎细胞因子（TNF-α、IL-6、IL-12p70 和 IL-1β）的水平。这些结果表明，维生素 D3 可能是一种有潜在用途的抗病毒化合物。
