Scholz G, Marek H, Grossmann K D, Kellner K
Abteilung Endokrinologie/Stoffwechselerkrankungen, Bereiches Medizin der Karl-Marx-Universität Leipzig.
Z Gesamte Inn Med. 1990 Jul 1;45(13):378-81.
In 11 healthy volunteers the effects of oral verapamil administration (4 X 80 mg/d) on plasma or serum concentrations of ionized, pH-corrected ionized and total calcium, on intact and midregional parathyroid hormone and on 24 h urinary excretion of calcium were investigated at rest. In addition the concentrations of ionized, pH-corrected ionized and total serum calcium were analyzed under bicycle exercise. Verapamil resulted in an increase of total serum calcium (p less than 0.02) and a fall in midregional parathyroid hormone concentrations (p less than 0.02) at rest. There was also found a statistically significant elevation of both ionized (p less than 0.05) and pH-corrected ionized (p less than 0.05) plasma calcium, and a slight increase in the total calcium under exercise (p less than 0.1). Before verapamil a significant negative correlation between total calcium and midregional parathyroid hormone was evident (r = -0.618; p less than 0.05), which however could not be clearly discerned after verapamil.
在11名健康志愿者中，研究了口服维拉帕米（4×80mg/天）对静息状态下血浆或血清中离子钙、经pH校正的离子钙和总钙浓度、完整甲状旁腺激素和甲状旁腺激素中区段浓度以及24小时尿钙排泄的影响。此外，还分析了自行车运动状态下离子钙、经pH校正的离子钙和血清总钙的浓度。维拉帕米导致静息状态下血清总钙升高（p<0.02），甲状旁腺激素中区段浓度降低（p<0.02）。还发现运动时离子钙（p<0.05）和经pH校正的离子钙（p<0.05）血浆浓度有统计学意义的升高，总钙略有增加（p<0.1）。在服用维拉帕米之前，总钙与甲状旁腺激素中区段之间存在显著的负相关（r=-0.618；p<0.05），然而服用维拉帕米后这种相关性无法清晰辨别。
