Department of Psychosomatic Medicine, University Medicine Charité, Berlin, Germany.
Biol Psychol. 2012 Apr;90(1):50-9. doi: 10.1016/j.biopsycho.2012.02.011. Epub 2012 Feb 23.
Aversive pavlovian delay conditioning was investigated in a sample of 11 criminal psychopaths as identified by using the Psychopathy Checklist-Revised and 11 matched healthy controls. A painful electric stimulus served as unconditioned stimulus and neutral faces as conditioned stimuli. Event-related potentials, startle response potentiation, skin conductance response, corrugator activity, and heart rate were assessed, along with valence, arousal, and contingency ratings of the CS and US. Compared to healthy controls, psychopathic subjects failed to differentiate between the CS+/CS- as shown by an absence of a conditioned response in startle potentiation and skin conductance measures. Through use of a fear-eliciting US, these data confirm previous findings of a deficient capacity to form associations between neutral and aversive events in psychopathy that appears unrelated to cognitive deficits and is consistent with hypothesized frontolimbic deficits in the disorder.
在一组 11 名犯罪性精神病患者（通过使用《精神病检查表修订版》确定）和 11 名匹配的健康对照中，研究了厌恶的巴甫洛夫式延迟条件作用。疼痛的电刺激作为非条件刺激，中性面孔作为条件刺激。评估了事件相关电位、惊跳反应增强、皮肤电导反应、皱眉肌活动和心率，以及 CS 和 US 的效价、唤醒度和关联性评分。与健康对照组相比，精神病患者未能区分 CS+/CS-，这表现在惊跳增强和皮肤电导测量中缺乏条件反应。通过使用引起恐惧的 US，这些数据证实了先前关于精神病患者在将中性和厌恶事件之间形成关联的能力缺陷的发现，这似乎与认知缺陷无关，与该障碍中假设的额叶边缘缺陷一致。
