Mens Jenthe, Masthoff Erik, Bogaerts Stefan, Heus Pauline
Department of Developmental Psychology, Tilburg University, Tilburg, Netherlands.
Fivoor Science and Treatment Innovation, Fivoor, Rotterdam, Netherlands.
Front Psychiatry. 2025 Apr 29;16:1580615. doi: 10.3389/fpsyt.2025.1580615. eCollection 2025.
Forensic psychiatry aims to reduce criminogenic risks and enhance societal safety. While effective at a macro level, crime recidivism rates among forensic patients remain substantial. This underlines the need for innovation, with growing interest in the use of physiological biomarkers. To identify the extent (size), range, (variety), and nature (characteristics) of evidence on the use of physiological biomarkers in forensic psychiatry, a systematic scoping review was conducted following JBI methodology and PRISMA-ScR guidance. Data on study characteristics and results were extracted by two independent reviewers from 431 primary research studies published in scientific journals and dissertations. Most studies were conducted in North America (53.4%) and Europe (41.3%). The majority employed an observational design (95.6%) and were cross-sectional (87.7%). Studies predominantly focused on males (84.9%) and adults (85.9%). The most common diagnoses were psychopathy/antisocial personality disorder (51.7%) and sexual disorders (21.8%). Brain activity served as a biomarker outcome in 51.3% of studies, followed by peripheral sympathetic arousal (29.2%) and peripheral sexual arousal (13.8%). Biomarker assessment methods reflected these findings. Etiologic biomarker functions were most common (77.2%), followed by diagnostic functions (12.7%). Findings reveal several gaps in the existing scientific literature. Specifically, more experimental and longitudinal research is needed to integrate physiological biomarkers into e.g., interventions, effect monitoring, and (risk) assessment. Also, a greater focus on juveniles, patients with psychotic and substance use disorders, and the use of newer biomarker assessment methods measuring peripheral arousal is essential to advance the field.
https://osf.io/, 10.17605/OSF.IO/46QBU.
法医精神病学旨在降低犯罪风险并增强社会安全。虽然在宏观层面上是有效的，但法医患者的犯罪再犯率仍然很高。这凸显了创新的必要性，人们对使用生理生物标志物的兴趣日益浓厚。为了确定法医精神病学中使用生理生物标志物的证据的范围（大小）、种类（多样性）和性质（特征），我们按照JBI方法和PRISMA-ScR指南进行了一项系统的范围综述。两名独立评审员从发表在科学期刊和学位论文中的431项初步研究中提取了有关研究特征和结果的数据。大多数研究在北美（53.4%）和欧洲（41.3%）进行。大多数研究采用观察性设计（95.6%）且为横断面研究（87.7%）。研究主要集中在男性（84.9%）和成年人（85.9%）。最常见的诊断是精神病态/反社会人格障碍（51.7%）和性障碍（21.8%）。51.3%的研究将大脑活动作为生物标志物结果，其次是外周交感神经兴奋（29.2%）和外周性兴奋（13.8%）。生物标志物评估方法也反映了这些结果。病因生物标志物功能最为常见（77.2%），其次是诊断功能（12.7%）。研究结果揭示了现有科学文献中的一些差距。具体而言，需要更多的实验性和纵向研究，以便将生理生物标志物整合到例如干预措施、效果监测和（风险）评估中。此外，更多地关注青少年、患有精神病和物质使用障碍的患者，以及使用测量外周兴奋的更新的生物标志物评估方法对于推动该领域的发展至关重要。
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