Ondrus P, Gregorová H, Gábor D, Laca L
Regional Hospital of Public Health, Banská Bystrica, Czechoslovakia.
Vasa. 1990;19(3):229-33.
The aim of the study was to assess, on the basis of changes in the resting arterial and venous values and arteriovenous difference of pH, pCO2, pO2, lactate, pyruvate and the lactate/pyruvate ratio in blood collected from the common femoral artery and vein before and after therapy, and at 4 weeks after therapy, the long-term effect of intraarterial vasodilator administration in 42 lower extremities with the chronic ischaemic syndrome in stages IIb, III and IV according to Fontaine. Ten intraarterial vasodilator infusions containing 300 mg trimecaine and 60 mg papaverine in 200 ml of saline led to an increase in oxygen extraction from circulating blood, as demonstrated by a statistically significant rise in arteriovenous pO2 difference persisting as long as 4 weeks after termination of therapy. The finding of increased CO2 release and the permanent drop in venous lactate levels suggest stimulation of aerobic metabolism of the chronically ischaemic tissue of the lower extremity induced by intraarterial vasodilator administration.
本研究的目的是，根据治疗前后以及治疗后4周从股总动脉和静脉采集的血液中静息动脉和静脉值的变化以及pH、pCO2、pO2、乳酸、丙酮酸和乳酸/丙酮酸比值的动静脉差值，评估动脉内给予血管扩张剂对42条根据Fontaine分级处于IIb、III和IV期慢性缺血综合征下肢的长期影响。在200 ml生理盐水中含有300 mg三甲卡因和60 mg罂粟碱的10次动脉内血管扩张剂输注导致从循环血液中提取的氧气增加，治疗终止后长达4周的动静脉pO2差值有统计学意义的升高证明了这一点。二氧化碳释放增加以及静脉乳酸水平持续下降的发现表明，动脉内给予血管扩张剂可刺激下肢慢性缺血组织的有氧代谢。
